Introduction：Basic information about CAS 943764-99-6|Acebilustat, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Acebilustat |
|---|
| CAS Number | 943764-99-6 | Molecular Weight | 481.542 |
|---|
| Density | 1.3±0.1 g/cm3 | Boiling Point | 649.1±65.0 °C at 760 mmHg |
|---|
| Molecular Formula | C29H27N3O4 | Melting Point | / |
|---|
| MSDS | / | Flash Point | 346.3±34.3 °C |
|---|
Names
| Name | acebilustat |
|---|
| Synonym | More Synonyms |
|---|
Acebilustat BiologicalActivity
| Description | Acebilustat is a leukotriene A4 hydrolase inhibitor, used for an oral antiinflammatory drug. |
|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology |
|---|
| In Vitro | Acebilustat is a leukotriene A4 hydrolase inhibitor, which is safe and well tolerated in phase 1 trial[1]. Acebilustat is an antiinflammatory drug in development for the treatment of CF and other diseases. It is a potent inhibitor of the enzyme leukotriene A4 hydrolase (LTA4H), which catalyzes the rate-limiting step in the formation of leukotriene B4 (LTB4), a potent chemoattractant and activator of inflammatory immune cells including neutrophils[2]. |
|---|
| References | [1]. Elborn JS, et al. Phase 1 Studies of Acebilustat: Biomarker Response and Safety in Patients with Cystic Fibrosis. Clin Transl Sci. 2016 Nov 2 [2]. Elborn JS, et al. Phase I Studies of Acebilustat: Pharmacokinetics, Pharmacodynamics, Food Effect, and CYP3A Induction. Clin Transl Sci. 2016 Oct 28. |
|---|
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|
| Boiling Point | 649.1±65.0 °C at 760 mmHg |
|---|
| Molecular Formula | C29H27N3O4 |
|---|
| Molecular Weight | 481.542 |
|---|
| Flash Point | 346.3±34.3 °C |
|---|
| Exact Mass | 481.200165 |
|---|
| LogP | 4.37 |
|---|
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
|---|
| Index of Refraction | 1.654 |
|---|
| InChIKey | GERJIEKMNDGSCS-DQEYMECFSA-N |
|---|
| SMILES | O=C(O)c1ccc(CN2CC3CC2CN3Cc2ccc(Oc3ccc(-c4ncco4)cc3)cc2)cc1 |
|---|
| Storage condition | 2-8℃ |
|---|
Synonyms
| Benzoic acid, 4-[[(1S,4S)-5-[[4-[4-(2-oxazolyl)phenoxy]phenyl]methyl]-2,5-diazabicyclo[2.2.1]hept-2-yl]methyl]- |
| 4-{[(1S,4S)-5-{4-[4-(1,3-Oxazol-2-yl)phenoxy]benzyl}-2,5-diazabicyclo[2.2.1]hept-2-yl]methyl}benzoic acid |
| acebilustat |
