CAS 106577-39-3|Hederacolchiside A1
Introduction：Basic information about CAS 106577-39-3|Hederacolchiside A1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Hederacolchiside A1 | ||
|---|---|---|---|
| CAS Number | 106577-39-3 | Molecular Weight | 897.097 |
| Density | 1.36±0.1 g/cm3 (20 ºC 760 Torr) | Boiling Point | 967.2±65.0 °C at 760 mmHg |
| Molecular Formula | C47H76O16 | Melting Point | 253-255℃ (methanol , water ) |
| MSDS | / | Flash Point | 276.2±27.8 °C |
Names
| Name | Hederacolchiside A1 |
|---|---|
| Synonym | More Synonyms |
Hederacolchiside A1 BiologicalActivity
| Description | Hederacolchiside A1, isolated from Pulsatilla chinensis, suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway[1]. Hederacolchiside A1 has antischistosomal activity, affecting parasite viability both in vivo and in vitro[2]. |
|---|---|
| Related Catalog | Signaling Pathways >>PI3K/Akt/mTOR >>mTORSignaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerResearch Areas >>InfectionSignaling Pathways >>PI3K/Akt/mTOR >>PI3KSignaling Pathways >>PI3K/Akt/mTOR >>Akt |
| Target | PI3K Akt mTOR |
| In Vitro | Hederacolchiside A1 reduces the mitochondrial membrane potential and Bcl-2 protein levels, whereas cleaved caspase-3 was higher[1]. Hederacolchiside A1 effectively inhibits the phosphorylations of phosphatidylinositol 3 kinase (PI3K), protein kinase B (Akt), and mammalian target of rapamycin (mTOR) [1]. |
| In Vivo | hederacolchiside A1 (3.0, 4.5, and 6.0 mg/kg, ip) can significantly inhibit the weight of tumor in an H22 xenograft model[1]. Hederacolchiside A1 (3.25, 7.5, and 15.0 mg/kg, ig) can significantly inhibit the weight of tumor in nude mice xenograft tumor models using human breast carcinoma MCF-7 cells[1]. |
| References | [1]. Yan-Er Wang, et al. Hederacolchiside A1 suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway. Chinese Herbal Medicines.Volume 10, Issue 2, April 2018, Pages 215-222 [2]. Kang N, et al. Antischistosomal Properties of Hederacolchiside A1 Isolated from Pulsatilla chinensis. Molecules. 2018 Jun 13;23(6). |
Chemical & Physical Properties
| Density | 1.36±0.1 g/cm3 (20 ºC 760 Torr) |
|---|---|
| Boiling Point | 967.2±65.0 °C at 760 mmHg |
| Melting Point | 253-255℃ (methanol , water ) |
| Molecular Formula | C47H76O16 |
| Molecular Weight | 897.097 |
| Flash Point | 276.2±27.8 °C |
| Exact Mass | 896.513306 |
| LogP | 7.36 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Index of Refraction | 1.610 |
| InChIKey | FYSAXYBPXKLMJO-IFECXJOTSA-N |
| SMILES | CC1OC(OC2C(OC3CCC4(C)C(CCC5(C)C4CC=C4C6CC(C)(C)CCC6(C(=O)O)CCC45C)C3(C)C)OCC(OC3OC(CO)C(O)C(O)C3O)C2O)C(O)C(O)C1O |
| Storage condition | 2-8℃ |
| Water Solubility | Insuluble (3.9E-4 g/L) (25 ºC) |
Synonyms
| (3β,5ξ,18α)-3-{[6-Deoxy-α-L-mannopyranosyl-(1->2)-[β-D-glucopyranosyl-(1->4)]-α-L-arabinopyranosyl]oxy}olean-12-en-28-oic acid |
| Olean-12-en-28-oic acid, 3-[[O-6-deoxy-α-L-mannopyranosyl-(1->2)-O-[β-D-glucopyranosyl-(1->4)]-α-L-arabinopyranosyl]oxy]-, (3β,5ξ,18α)- |
