Introduction：Basic information about CAS 1446321-46-5|GBT-440, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | GBT-440 |
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| CAS Number | 1446321-46-5 | Molecular Weight | 337.372 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 539.2±50.0 °C at 760 mmHg |
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| Molecular Formula | C19H19N3O3 | Melting Point | / |
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| MSDS | / | Flash Point | 279.9±30.1 °C |
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Names
| Name | voxelotor |
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| Synonym | More Synonyms |
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GBT-440 BiologicalActivity
| Description | GBT 440 (Voxelotor) is an orally bioavailable modulator of sickle cell hemoglobin. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Cardiovascular Disease |
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| References | [1]. Metcalf B, et al. Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin. ACS Med Chem Lett. 2017 Jan 23;8(3):321-326. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 539.2±50.0 °C at 760 mmHg |
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| Molecular Formula | C19H19N3O3 |
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| Molecular Weight | 337.372 |
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| Flash Point | 279.9±30.1 °C |
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| Exact Mass | 337.142639 |
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| LogP | 2.85 |
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| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
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| Index of Refraction | 1.617 |
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| InChIKey | FWCVZAQENIZVMY-UHFFFAOYSA-N |
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| SMILES | CC(C)n1nccc1-c1ncccc1COc1cccc(O)c1C=O |
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| Storage condition | -20℃ |
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Synonyms
| Benzaldehyde, 2-hydroxy-6-[[2-[1-(1-methylethyl)-1H-pyrazol-5-yl]-3-pyridinyl]methoxy]- |
| 2-Hydroxy-6-{[2-(1-isopropyl-1H-pyrazol-5-yl)-3-pyridinyl]methoxy}benzaldehyde |
| voxelotor |
| GBT-440 |
| GBT 440 |
