Introduction：Basic information about CAS 202592-23-2|JQ-1 carboxylic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | JQ-1 carboxylic acid |
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| CAS Number | 202592-23-2 | Molecular Weight | 400.882 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 661.6±65.0 °C at 760 mmHg |
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| Molecular Formula | C19H17ClN4O2S | Melting Point | / |
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| MSDS | / | Flash Point | 353.9±34.3 °C |
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Names
| Name | (+)-JQ1 carboxylic acid |
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| Synonym | More Synonyms |
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JQ-1 carboxylic acid BiologicalActivity
| Description | JQ-1 carboxylic acid is a highly potent, selective and cell-permeable BRD4 inhibitor with IC50s of 77 nM and 33 nM for BRD4(1) and BRD4(2), respectively. |
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| Related Catalog | Signaling Pathways >>Epigenetics >>Epigenetic Reader DomainResearch Areas >>Cancer |
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| References | [1]. James Elliott Bradner, et al. Male contraceptive compositions and methods of use. Patent WO 2011143657 A1. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 661.6±65.0 °C at 760 mmHg |
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| Molecular Formula | C19H17ClN4O2S |
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| Molecular Weight | 400.882 |
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| Flash Point | 353.9±34.3 °C |
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| Exact Mass | 400.076080 |
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| LogP | 2.79 |
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| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
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| Index of Refraction | 1.737 |
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| InChIKey | LJOSBOOJFIRCSO-AWEZNQCLSA-N |
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| SMILES | Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=NC(CC(=O)O)c1nnc(C)n1-2 |
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| Storage condition | 2-8℃ |
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Synonyms
| 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, (6S)- |
| [(6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetic acid |
| JQ-1 (carboxylic acid) |
