Introduction：Basic information about CAS 108524-93-2|Ilexsaponin A, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Ilexsaponin A |
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| CAS Number | 108524-93-2 | Molecular Weight | 664.823 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 788.1±60.0 °C at 760 mmHg |
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| Molecular Formula | C36H56O11 | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | 240.1±26.4 °C |
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| Symbol |
GHS06 | Signal Word | Danger |
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Names
| Name | Ilexsaponin A |
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| Synonym | More Synonyms |
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Ilexsaponin A BiologicalActivity
| Description | Ilexsaponin A, isolated from the root of Ilex pubescens, attenuates ischemia-reperfusion-induced myocardial injury through anti-apoptotic pathway. Ilexsaponin A can reduce myocardial infarct size, lower the serum levels of LDH, AST and CK-MB, increase cellular viability and inhibit apoptosis in hypoxia/reoxygenation cardiomyocytes[1]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>Apoptosis |
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| In Vitro | Ilexsaponin A significantly reduces proapoptotic proteins including caspase-3, cleaved caspase-3 and bax and increases anti-apoptotic protein bcl-2 in hypoxia/reoxygenation cardiomyocytes. Ilexsaponin A treatment increases the expression levels of p-Akt in hypoxia/reoxygenation cellular model and myocardial ischemia/reperfusion animal model[1]. |
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| In Vivo | Ilexsaponin A (10 or 40 mg/kg) reduce the myocardial infarct size in a dose dependent manner in male Sprague-Dawley rats weighing 280-320 g[1]. |
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| References | [1]. Zhang SW, et al. Ilexsaponin A attenuates ischemia-reperfusion-induced myocardial injury through anti-apoptotic pathway. PLoS One. 2017 Feb 9;12(2):e0170984. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 788.1±60.0 °C at 760 mmHg |
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| Molecular Formula | C36H56O11 |
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| Molecular Weight | 664.823 |
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| Flash Point | 240.1±26.4 °C |
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| Exact Mass | 664.382263 |
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| LogP | 5.11 |
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| Vapour Pressure | 0.0±6.2 mmHg at 25°C |
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| Index of Refraction | 1.611 |
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| InChIKey | AWFZJSUJFSUBQU-MOJLLMCOSA-N |
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| SMILES | CC1CCC2(C(=O)OC3OC(CO)C(O)C(O)C3O)CCC3(C)C(=CCC4C5(C)CCC(O)C(C)(C(=O)O)C5CCC43C)C2C1(C)O |
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| Storage condition | 2-8℃ |
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Safety Information
| Symbol |
GHS06 |
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| Signal Word | Danger |
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| Hazard Statements | H301 |
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| Precautionary Statements | P301 + P310 |
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| RIDADR | UN 2811 6.1 / PGIII |
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Synonyms
| 1-O-[(3β,5ξ)-3,19,23-Trihydroxy-23,28-dioxours-12-en-28-yl]-β-D-glucopyranose |
| β-D-Glucopyranose, 1-O-[(3β,5ξ)-3,19,23-trihydroxy-23,28-dioxours-12-en-28-yl]- |
| Ilexsaponin A1 |
