Introduction：Basic information about CAS 1708971-55-4|FGF-401, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | FGF-401 |
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| CAS Number | 1708971-55-4 | Molecular Weight | 506.557 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 852.1±65.0 °C at 760 mmHg |
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| Molecular Formula | C25H30N8O4 | Melting Point | / |
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| MSDS | / | Flash Point | 469.1±34.3 °C |
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Names
| Name | FGF-401 |
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| Synonym | More Synonyms |
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FGF-401 BiologicalActivity
| Description | FGF-401 is an inhibitor of FGFR4 extracted from patent WO2015059668A1, compound example 83; has an IC50 of 1.9 nM. |
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| Related Catalog | Signaling Pathways >>Protein Tyrosine Kinase/RTK >>FGFRResearch Areas >>Cancer |
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| Target | FGFR4:1.9 nM (IC50) |
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| In Vivo | FGF-401 is a FGFR4 inhibitor developed for the treatment of solid tumor. FGF-401 is a FGFR4 inhibitor in phase I/II clinical studies for the treatment of positive FGFR4 and KLB expresion solid tumors and hepatocellular carcinoma[1]. |
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| References | [1]. WO2015059668A1 |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 852.1±65.0 °C at 760 mmHg |
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| Molecular Formula | C25H30N8O4 |
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| Molecular Weight | 506.557 |
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| Flash Point | 469.1±34.3 °C |
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| Exact Mass | 506.239014 |
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| LogP | -0.15 |
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| Vapour Pressure | 0.0±3.2 mmHg at 25°C |
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| Index of Refraction | 1.654 |
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| InChIKey | BHKDKKZMPODMIQ-UHFFFAOYSA-N |
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| SMILES | COCCNc1cc(NC(=O)N2CCCc3cc(CN4CCN(C)CC4=O)c(C=O)nc32)ncc1C#N |
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| Storage condition | -20℃ |
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Synonyms
| 1,8-Naphthyridine-1(2H)-carboxamide, N-[5-cyano-4-[(2-methoxyethyl)amino]-2-pyridinyl]-7-formyl-3,4-dihydro-6-[(4-methyl-2-oxo-1-piperazinyl)methyl]- |
| N-{5-Cyano-4-[(2-methoxyethyl)amino]-2-pyridinyl}-7-formyl-6-[(4-methyl-2-oxo-1-piperazinyl)methyl]-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide |
| FGF401 |
