CAS 945966-46-1|Apararenone

Introduction：Basic information about CAS 945966-46-1|Apararenone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Apararenone BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Apararenone
CAS Number	945966-46-1	Molecular Weight	364.391
Density	1.4±0.1 g/cm3	Boiling Point	594.3±60.0 °C at 760 mmHg
Molecular Formula	C₁₇H₁₇FN₂O₄S	Melting Point	/
MSDS	/	Flash Point	313.2±32.9 °C

Names

Name	Apararenone
Synonym	More Synonyms

Apararenone BiologicalActivity

Description	Apararenone (MT-3995) is a novel non-steroidal mineralocorticoid receptor antagonists under development for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis.
Related Catalog	Signaling Pathways >>Metabolic Enzyme/Protease >>Mineralocorticoid ReceptorResearch Areas >>Metabolic DiseaseResearch Areas >>Cardiovascular Disease
Target	Mineralocorticoid receptor[1]
In Vivo	Recently, a phase II clinical trial has been initiated among patients with non-alcoholic steatohepatitis (NASH) in Japan[1].
References	[1]. Kolkhof P, et al. 30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Mineralocorticoid receptor antagonists: 60 years of research and development. J Endocrinol. 2017 Jul;234(1):T125-T140.

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Boiling Point	594.3±60.0 °C at 760 mmHg
Molecular Formula	C₁₇H₁₇FN₂O₄S
Molecular Weight	364.391
Flash Point	313.2±32.9 °C
Exact Mass	364.089294
LogP	1.26
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.610
InChIKey	AZNHWXAFPBYFGH-UHFFFAOYSA-N
SMILES	CC1(C)Oc2cc(NS(C)(=O)=O)ccc2N(c2ccc(F)cc2)C1=O
Storage condition	2-8℃

Synonyms

Methanesulfonamide, N-[4-(4-fluorophenyl)-3,4-dihydro-2,2-dimethyl-3-oxo-2H-1,4-benzoxazin-7-yl]-

UNII:832663U2NB

832663U2NB

N-[4-(4-Fluorophenyl)-2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl]methanesulfonamide

apararenone

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