Introduction：Basic information about CAS 108524-94-3|IlexgeninA, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | IlexgeninA |
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| CAS Number | 108524-94-3 | Molecular Weight | 502.683 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 653.3±55.0 °C at 760 mmHg |
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| Molecular Formula | C30H46O6 | Melting Point | / |
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| MSDS | / | Flash Point | 362.9±28.0 °C |
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Names
| Name | Ilexgenin A |
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| Synonym | More Synonyms |
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IlexgeninA BiologicalActivity
| Description | Ilexgenin A is a pentacyclic triterpenoid, which extracted from Ilex hainanensis Merr. Ilexgenin A can be used for the research of inflammation and cancer[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology |
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| In Vitro | Ilexgenin A (0~100 μM; 24 hours; HT 29 and HCT 116 cells) effectively decreases cell viability in HT 29 and HCT 116 cells[1]. Ilexgenin A (12.5~50 μM; 24 hours; HT 29 cells) downregulates the expression of SREBP-1, inhibits the translocation of SREBP-1 to the nucleus and decreases the content of TG[1]. Ilexgenin A (12.5~50 μM; HT 29 and HCT 116 cells) induces cell cycle arrest at G1 phase in colon cancer cells[1]. Ilexgenin A (12.5~50 μM; 24 hours; HCT 116 cells) modulates lipid metabolism. Ilexgenin A (50 μM; 24 hours; HT 29 and HCT 116 cells) regulates SREBP-1 by inhibiting HIF1α[1]. Ilexgenin A inhibits fatty acids synthesis[1]. Cell Viability Assay[1] Cell Line: HT 29 and HCT 116 cells Concentration: 0~100 μM Incubation Time: 24 hours Result: Effectively decreased cell viability in HT 29 and HCT 116 cells. Western Blot Analysis[1] Cell Line: HT 29 cells Concentration: 12.5~50 μM Incubation Time: 24 hours Result: Downregulated the expression of SREBP-1. RT-PCR[1] Cell Line: HT 29 cells Concentration: 12.5~50 μM Incubation Time: 24 hours Result: Decreased the content of TG. Immunofluorescence[1] Cell Line: HT 29 cells Concentration: 12.5~50 μM Incubation Time: 24 hours Result: Inhibited the translocation of SREBP-1 to the nucleus. |
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| In Vivo | Ilexgenin A (20 mg/kg) ameliorates the AOM/DSS induced carcinogenesis. Ilexgenin A can regulate lipid metabolism. Ilexgenin A decreases the expression of SREBP-1 and HIF 1α in AOM/DSS mice[1]. |
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| References | [1]. Zhang L, et al. Ilexgenin A prevents early colonic carcinogenesis and reprogramed lipid metabolism through HIF1α/SREBP-1. Phytomedicine. 2019;63:153011. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 653.3±55.0 °C at 760 mmHg |
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| Molecular Formula | C30H46O6 |
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| Molecular Weight | 502.683 |
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| Flash Point | 362.9±28.0 °C |
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| Exact Mass | 502.329437 |
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| LogP | 5.77 |
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| Vapour Pressure | 0.0±4.4 mmHg at 25°C |
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| Index of Refraction | 1.587 |
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| InChIKey | UIEGOKVPCRANSU-XUFMHOFVSA-N |
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| SMILES | CC1CCC2(C(=O)O)CCC3(C)C(=CCC4C5(C)CCC(O)C(C)(C(=O)O)C5CCC43C)C2C1(C)O |
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| Storage condition | 2-8℃ |
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Synonyms
| Myriaboric acid |
| Urs-12-ene-24,28-dioic acid, 3,19-dihydroxy-, (3β)- |
| (3β)-3,19-Dihydroxyurs-12-ene-24,28-dioic acid |
