Introduction：Basic information about CAS 1034688-30-6|GSK 2018682, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | GSK 2018682 |
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| CAS Number | 1034688-30-6 | Molecular Weight | 440.88 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C22H21ClN4O4 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | GSK-2018682 |
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| Synonym | More Synonyms |
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GSK 2018682 BiologicalActivity
| Description | GSK2018682 is an agonist for S1P1 and S1P5 receptor with pEC50s of 7.7 and 7.2, respectively, and has no agonist activity towards human S1P2, S1P3, or S1P4. GSK2018682 is used in the research of multiple sclerosis. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>LPL ReceptorResearch Areas >>Inflammation/Immunology |
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| Target | pEC50: 7.7 (S1P1 receptor), 7.2 (S1P5 receptor)[1] |
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| In Vitro | GSK2018682 is an agonist for S1P1 and S1P5 receptor with pEC50s of 7.7 and 7.2, respectively, and has no agonist activity towards human S1P2, S1P3, or S1P4[1]. |
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| References | [1]. Xu J, et al. Safety, pharmacokinetics, pharmacodynamics, and bioavailability of GSK2018682, a sphingosine-1-phosphate receptor modulator, in healthy volunteers. Clin Pharmacol Drug Dev. 2014 May;3(3):170-8. |
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Chemical & Physical Properties
| Molecular Formula | C22H21ClN4O4 |
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| Molecular Weight | 440.88 |
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| InChIKey | NFIGDBFIDKDNIG-UHFFFAOYSA-N |
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| SMILES | CC(C)Oc1ncc(-c2nc(-c3cccc4c3ccn4CCCC(=O)O)no2)cc1Cl |
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| Storage condition | 2-8℃ |
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Synonyms
