Introduction：Basic information about CAS 1000308-25-7|Landipirdine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Landipirdine |
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| CAS Number | 1000308-25-7 | Molecular Weight | 362.42 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 564.7±50.0 °C at 760 mmHg |
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| Molecular Formula | C18H19FN2O3S | Melting Point | / |
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| MSDS | / | Flash Point | 295.3±30.1 °C |
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Names
| Name | Landipirdine |
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| Synonym | More Synonyms |
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Landipirdine BiologicalActivity
| Description | Landipirdine is a selective antagonist of 5-HT6R. Landipirdine has great effect on the hERG pharmacophore[1]. |
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| Related Catalog | Research Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT Receptor |
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| References | [1]. Harris RN 3rd, et al. Highly potent, non-basic 5-HT6 ligands. Site mutagenesis evidence for a second binding mode at 5-HT6 for antagonism. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3436-40. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 564.7±50.0 °C at 760 mmHg |
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| Molecular Formula | C18H19FN2O3S |
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| Molecular Weight | 362.42 |
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| Flash Point | 295.3±30.1 °C |
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| Exact Mass | 362.110046 |
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| LogP | 2.63 |
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| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
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| Index of Refraction | 1.593 |
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| InChIKey | MTTHRRVVGMPYQG-ZDUSSCGKSA-N |
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| SMILES | NC(=O)NCC1CCCc2cc(S(=O)(=O)c3cccc(F)c3)ccc21 |
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Synonyms
| 1-({(1R)-6-[(3-Fluorophenyl)sulfonyl]-1,2,3,4-tetrahydro-1-naphthalenyl}methyl)urea |
| Landipirdine |
| UNII:J0NX985GDI |
| J0NX985GDI |
| N-{[(1R)-6-(3-fluorobenzenesulfonyl)-1,2,3,4-tetrahydronaphthalen-1- yl]methyl}urea |
| RO5025181 |
| SYN120 |
| Urea, N-[[(1R)-6-[(3-fluorophenyl)sulfonyl]-1,2,3,4-tetrahydro-1-naphthalenyl]methyl]- |
| 10424 |
| RO5025181-000 |
