CAS 1079043-55-2|AVP-786

Introduction：Basic information about CAS 1079043-55-2|AVP-786, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. AVP-786 BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	AVP-786
CAS Number	1079043-55-2	Molecular Weight	277.434
Density	1.1±0.1 g/cm3	Boiling Point	394.9±42.0 °C at 760 mmHg
Molecular Formula	C₁₈H₁₉D₆NO	Melting Point	/
MSDS	/	Flash Point	116.2±30.2 °C

Names

Name	Deudextromethorphan
Synonym	More Synonyms

AVP-786 BiologicalActivity

Description	Deudextromethorphan (AVP-786) is a deuterated form of dextromethorphan/quinidine (AVP-923, Nuedexta). Deudextromethorphan, a glutamate-targeting agent, is an orally active N-methyl-D-aspartate (NMDA) receptor antagonist. Deudextromethorphan can be used for the research of Pseudo-Bulbar Affect, traumatic brain injury, behavioral disinhibition and agitation in AD[1][2][3].
Related Catalog	Signaling Pathways >>Neuronal Signaling >>iGluRResearch Areas >>Neurological DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>iGluR
References	[1]. Khoury R, et al. AVP-786 as a promising treatment option for Alzheimer's Disease including agitation. Expert Opin Pharmacother. 2021 May;22(7):783-795. [2]. Garay RP, et al. AVP-786 for the treatment of agitation in dementia of the Alzheimer's type. Expert Opin Investig Drugs. 2017 Jan;26(1):121-132. [3]. Hecking J, et al. Emerging Therapeutics Based on the Amino Acid Neurotransmitter System: An Update on the Pharmaceutical Pipeline for Mood Disorders. Chronic Stress (Thousand Oaks). 2021 Jun 2;5:24705470211020446.

Description

Deudextromethorphan (AVP-786) is a deuterated form of dextromethorphan/quinidine (AVP-923, Nuedexta). Deudextromethorphan, a glutamate-targeting agent, is an orally active N-methyl-D-aspartate (NMDA) receptor antagonist. Deudextromethorphan can be used for the research of Pseudo-Bulbar Affect, traumatic brain injury, behavioral disinhibition and agitation in AD[1][2][3].

Related Catalog

Signaling Pathways >>Neuronal Signaling >>iGluRResearch Areas >>Neurological DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>iGluR

References

[1]. Khoury R, et al. AVP-786 as a promising treatment option for Alzheimer's Disease including agitation. Expert Opin Pharmacother. 2021 May;22(7):783-795.

[2]. Garay RP, et al. AVP-786 for the treatment of agitation in dementia of the Alzheimer's type. Expert Opin Investig Drugs. 2017 Jan;26(1):121-132.

[3]. Hecking J, et al. Emerging Therapeutics Based on the Amino Acid Neurotransmitter System: An Update on the Pharmaceutical Pipeline for Mood Disorders. Chronic Stress (Thousand Oaks). 2021 Jun 2;5:24705470211020446.

Chemical & Physical Properties

Density	1.1±0.1 g/cm3
Boiling Point	394.9±42.0 °C at 760 mmHg
Molecular Formula	C₁₈H₁₉D₆NO
Molecular Weight	277.434
Flash Point	116.2±30.2 °C
Exact Mass	277.231262
LogP	4.11
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.585
InChIKey	MKXZASYAUGDDCJ-QNNIAVNKSA-N
SMILES	COc1ccc2c(c1)C13CCCCC1C(C2)N(C)CC3

Synonyms

Morphinan, 17-(methyl-d3)-3-(methyl-d3-oxy)-, (9α,13α,14α)-

UNII:427476LZFT

3-[(2H3)methoxy]-17-[(2H3)methyl]-ent-morphinan

Deudextromethorphan

427476LZFT

CTP-786

DEXTROMETHORPHAN D6

(9α,13α,14α)-17-(2H3)Methyl-3-[(2H3)methyloxy]morphinan

10288

d6-DM

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