CAS 227803-63-6|Aclerastide

Introduction：Basic information about CAS 227803-63-6|Aclerastide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Aclerastide BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Aclerastide
CAS Number	227803-63-6	Molecular Weight	913.031
Density	1.5±0.1 g/cm3	Boiling Point	/
Molecular Formula	C₄₂H₆₄N₁₂O₁₁	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	aclerastide
Synonym	More Synonyms

Aclerastide BiologicalActivity

Description	Aclerastide (DSC-127) is an angiotensin receptor agonist. Aclerastide also is a peptide analog of angiotensin II. Aclerastide can be used for the research of tissue regeneration in diabetic ulcers[1][2].
Related Catalog	Research Areas >>Inflammation/ImmunologySignaling Pathways >>GPCR/G Protein >>Angiotensin Receptor
In Vivo	Aclerastide (0.1 mg/wound; day for 5 days) shows superior efficacy in the db/db mouse model of wound healing[1]. Aclerastide (topically administered; 100 μL; once a day; for 14 days) elevates levels of reactive oxygen species and of active MMP-9[2]. Animal Model: db/db mice[2] Dosage: 100 μL Administration: Topically administered, once a day, for 14 days Result: Upregulated reactive oxygen species during inflammation. Increased the levels of the detrimental active MMP-9 in diabetic wounds.

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Molecular Formula	C₄₂H₆₄N₁₂O₁₁
Molecular Weight	913.031
Exact Mass	912.481750
LogP	1.46
Index of Refraction	1.660
InChIKey	RUBMHAHMIJSMHA-LBWFYSSPSA-N
SMILES	CCCCC(NC(=O)C(CCCN=C(N)N)NC(=O)C(N)CC(=O)O)C(=O)NC(Cc1ccc(O)cc1)C(=O)NC(C(=O)NC(Cc1cnc[nH]1)C(=O)N1CCCC1C(=O)O)C(C)CC

Synonyms

[3-(L-2-aminohexanoic acid)]angiotensin II-(1-7)-peptide

aclerastide

L-Proline, L-α-aspartyl-N5-(diaminomethylene)-L-ornithyl-L-norleucyl-L-tyrosyl-L-isoleucyl-L-histidyl-

L-α-Aspartyl-L-arginyl-L-norleucyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-proline

UNII:YYD6UT8T47

Recommended......