Introduction：Basic information about CAS 1491158-62-3|Fmoc-Lys(Pal-Glu-OtBu)-OH, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Fmoc-Lys(Pal-Glu-OtBu)-OH |
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| CAS Number | 1491158-62-3 | Molecular Weight | 792.055 |
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| Density | 1.1±0.1 g/cm3 | Boiling Point | 944.2±65.0 °C at 760 mmHg |
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| Molecular Formula | C46H69N3O8 | Melting Point | / |
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| MSDS | / | Flash Point | 524.8±34.3 °C |
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Names
| Name | (2S)-2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-6-{[(4S)-5-[(2-methyl-2-propanyl)oxy]-5-oxo-4-(palmitoylamino)pentanoyl]amino}hexanoic acid (non-preferred name) |
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| Synonym | More Synonyms |
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Fmoc-Lys(Pal-Glu-OtBu)-OH BiologicalActivity
| Description | Fmoc-Lys(Pal-Glu-OtBu)-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Lys(Pal-Glu-OtBu)-OH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC LinkerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | Cleavable |
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| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
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| References | [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. |
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Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
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| Boiling Point | 944.2±65.0 °C at 760 mmHg |
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| Molecular Formula | C46H69N3O8 |
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| Molecular Weight | 792.055 |
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| Flash Point | 524.8±34.3 °C |
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| Exact Mass | 791.508484 |
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| LogP | 11.05 |
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| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
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| Index of Refraction | 1.530 |
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| InChIKey | LQQXBYSAGYOQJW-ZAQUEYBZSA-N |
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| SMILES | CCCCCCCCCCCCCCCC(=O)NC(CCC(=O)NCCCCC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O)C(=O)OC(C)(C)C |
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Safety Information
Synonyms
| MFCD27952849 |
| N2-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N6-[N-(1-oxohexadecyl)-L-gamma-glutamyl]-L-lysine 1'-(1,1-dimethylethyl) ester |
| Fmoc-Lys(Pal-Glu-Otbu)-OH |
