CAS 1036204-61-1|Propargyl-PEG12-OH

Introduction:Basic information about CAS 1036204-61-1|Propargyl-PEG12-OH, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NamePropargyl-PEG12-OH
CAS Number1036204-61-1Molecular Weight584.694
Density1.1±0.1 g/cm3Boiling Point613.0±50.0 °C at 760 mmHg
Molecular FormulaC27H52O13Melting Point/
MSDS/Flash Point324.5±30.1 °C

Names

NamePropargyl-PEG13-alcohol
SynonymMore Synonyms

Propargyl-PEG12-OH BiologicalActivity

DescriptionPropargyl-PEG12-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
Related CatalogResearch Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker
Target

PEGs

In VitroPROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References

[1]. Sandanaraj BS, et al. Rational Design of Supramolecular Dynamic Protein Assemblies by Using a Micelle-AssistedActivity-Based Protein-Labeling Technology. Chemistry. 2018 Oct 26;24(60):16085-16096.

Chemical & Physical Properties

Density1.1±0.1 g/cm3
Boiling Point613.0±50.0 °C at 760 mmHg
Molecular FormulaC27H52O13
Molecular Weight584.694
Flash Point324.5±30.1 °C
Exact Mass584.340820
LogP-4.19
Vapour Pressure0.0±4.0 mmHg at 25°C
Index of Refraction1.467
InChIKeyFLGCCIHLPCYSCV-UHFFFAOYSA-N
SMILESC#CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO
Storage condition2-8°C

Synonyms

3,6,9,12,15,18,21,24,27,30,33,36-Dodecaoxanonatriacont-38-yn-1-ol
MFCD28334508
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