CAS 172451-37-5|Imperatoxin A
| Common Name | Imperatoxin A | ||
|---|---|---|---|
| CAS Number | 172451-37-5 | Molecular Weight | 3764.4 |
| Density | / | Boiling Point | / |
| Molecular Formula | C148H260N58O45S6 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | IMPERATOXIN A |
|---|
Imperatoxin A BiologicalActivity
| Description | Imperatoxin A, a peptide toxin derived from the venom of the African scorpion Pandinus imperator, activator of Ca2+-release channels/ryanodine receptors (RyRs)? enhances the influx of Ca2+ from the sarcoplasmatic reticulum into the cell[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Calcium Channel |
| Target | RyRs[1] |
| References | [1]. Georgina B Gurrola, et al. Imperatoxin A, a Cell-Penetrating Peptide from Scorpion Venom, as a Probe of Ca2+-Release Channels/Ryanodine Receptors. Pharmaceuticals (Basel). 2010 Apr 1;3(4):1093-1107. |
Chemical & Physical Properties
| Molecular Formula | C148H260N58O45S6 |
|---|---|
| Molecular Weight | 3764.4 |
| Appearance of Characters | lyophilized powder |
| Storage condition | −20°C |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H312-H332 |
| Precautionary Statements | P280 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn |
| Risk Phrases | 20/21/22 |
| Safety Phrases | 7-9-36/37 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles3
More Articles| Scorpion toxins targeted against the sarcoplasmic reticulum Ca(2+)-release channel of skeletal and cardiac muscle. Proc. Natl. Acad. Sci. U. S. A. 89 , 12185-12189, (1992) We report the purification of two peptides, called "imperatoxin inhibitor" and "imperatoxin activator," from the venom of the scorpion Pandinus imperator targeted against ryanodine receptor Ca(2+)-rel... | |
| Peptide probe of ryanodine receptor function. Imperatoxin A, a peptide from the venom of the scorpion Pandinus imperator, selectively activates skeletal-type ryanodine receptor isoforms. J. Biol. Chem. 270 , 28696-28704, (1995) We have used [3H]ryanodine binding experiments and single channel recordings to provide convergent descriptions of the effect of imperatoxin A (IpTxa), a approximately 5-kDa peptide from the venom of ... | |
| Primary structure and synthesis of Imperatoxin A (IpTx(a)), a peptide activator of Ca2+ release channels/ryanodine receptors. FEBS Lett. 405 , 385-389, (1997) We present the complete amino acid sequence of Imperatoxin A (IpTx(a)), a 33-amino-acid peptide from the venom of the scorpion P. imperator which activates Ca2+ release channels/ryanodine receptors (R... |
