Introduction：Basic information about CAS 37905-07-0|Jolkinolide A, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Jolkinolide A |
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| CAS Number | 37905-07-0 | Molecular Weight | 314.41864 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 479.5±45.0 °C at 760 mmHg |
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| Molecular Formula | C20H26O3 | Melting Point | / |
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| MSDS | / | Flash Point | 206.7±23.3 °C |
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Names
| Name | jolkinolide A |
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| Synonym | More Synonyms |
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Jolkinolide A BiologicalActivity
| Description | Jolkinolide A is a diterpenoid, can be extracted from the roots of Euphorbia fischeriana Steud. Jolkinolide A exhibits anti-tumor activity, by affecting on angiogenesis of tumor tissues. Jolkinolide A significantly inhibits the Akt-STAT3-mTOR signaling pathway and reduces the expression of VEGF in A549 cells[1]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>Protein Tyrosine Kinase/RTK >>VEGFR |
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| Target | VEGF[1] |
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| In Vitro | Jolkinolide A (20-100 μg/mL; 24 h) 提高 A549 细胞中 caspase-9 蛋白水平[1]。 Jolkinolide A (40-80 μg/mL; 24 h) 降低 A549 细胞中 Akt-STAT3-mTOR 蛋白的表达[1]。 Jolkinolide A (20-100 μg/mL; 24 h) 抑制人脐静脉内皮细胞 (HUVEC) 增殖和迁移，促进细胞凋亡[1]。 Western Blot Analysis[1] Cell Line: A549 cells Concentration: 20 μg/mL, 40 μg/mL, 60 μg/mL, 80 μg/mL, and 100 μg/mL Incubation Time: 24 hours Result: Promoted caspase-9 protein expression in cells at 20-100 μg/mL.Inhibited expression levels of Akt, STAT3, and mTOR proteins in cells at 40-80 μg/mL. |
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| In Vivo | Jolkinolide A (40 mg/kg; 腹腔注射; 每 3 天一次，持续 2 个月) 抑制小鼠A549细胞异种移植瘤模型中VEGF蛋白的表达[1]。 Animal Model: Female BALB/c nude mice (4-5 weeks old) injected with A549 cells[1] Dosage: 40 mg/kg Administration: Intraperitoneal injection; once every 3 days for 2 months Result: Significantly inhibited the expression of VEGF protein on the first, 10th, 30th, 45th, and 60th day of administration. |
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| References | [1]. Shen L, et al. Jolkinolide A and Jolkinolide B Inhibit Proliferation of A549 Cells and Activity of Human Umbilical Vein Endothelial Cells. Med Sci Monit. 2017 Jan 14;23:223-237. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 479.5±45.0 °C at 760 mmHg |
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| Molecular Formula | C20H26O3 |
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| Molecular Weight | 314.41864 |
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| Flash Point | 206.7±23.3 °C |
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| Exact Mass | 314.188202 |
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| LogP | 4.70 |
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| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
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| Index of Refraction | 1.579 |
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| InChIKey | OYXDHOVYZKWSRM-PHJMNMFVSA-N |
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| SMILES | CC1=C2C(=CC3C4(C)CCCC(C)(C)C4CCC34OC24)OC1=O |
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| Storage condition | 2-8℃ |
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Safety Information
Synonyms
| 2H-Oxireno[1,10a]phenanthro[3,2-b]furan-10(11bH)-one, 3,3a,4,5,6,7,7a,7b-octahydro-4,4,7a,11-tetramethyl-, (1aS,3aR,7aR,7bS,11bR)- |
| (5β,9β,10α,14β)-8,14:12,16-Diepoxyabieta-11,13(15)-dien-16-one |
| Jolkinolide A |
