CAS 101236-49-1|Kushenol K
Introduction：Basic information about CAS 101236-49-1|Kushenol K, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Kushenol K | ||
|---|---|---|---|
| CAS Number | 101236-49-1 | Molecular Weight | 472.527 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 722.4±60.0 °C at 760 mmHg |
| Molecular Formula | C26H32O8 | Melting Point | / |
| MSDS | / | Flash Point | 242.4±26.4 °C |
Names
| Name | Kushenol K |
|---|---|
| Synonym | More Synonyms |
Kushenol K BiologicalActivity
| Description | Kushenol K, a flavonoid antioxidant isolated from the roots of Sophora flavescens. Kushenol K is a cytochrome P-450 3A4 (CYP3A4) inhibitor with a Ki value of 1.35 μM[1]. Kushenol K shows weak antiviral activity against HSV-2 (EC50 of 147 μM)[2]. Kushenol K also inhibits the activity of SGLT1 and SGLT2[3]. |
|---|---|
| Related Catalog | Signaling Pathways >>Anti-infection >>HSVResearch Areas >>InfectionSignaling Pathways >>Metabolic Enzyme/Protease >>Cytochrome P450Research Areas >>Metabolic DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>SGLT |
| Target | HSV-2:147 μM (EC50) CYP3A4:1.35 μM (Ki) SGLT |
| In Vitro | When Midazolam is used as the substrate of CYP3A4, Kushenol K exhibits the strong inhibition with an IC50 values of 1.62 µM[1]. At a concentration of 50 μM, the inhibition rate of Kushenol K on SGLT1 is 29.7%, and the inhibition rate on SGLT2 is 43.7%[3]. |
| References | [1]. Yannan Li, et al. Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. Toxicol Lett. 2018 Sep 15;294:27-36. [2]. E R Woo, et al. A new prenylated flavonol from the roots of Sophora flavescens. J Nat Prod. 1998 Dec;61(12):1552-4. [3]. Seizo Sato, et al. Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens. Bioorg Med Chem. 2007 May 15;15(10):3445-9. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 722.4±60.0 °C at 760 mmHg |
| Molecular Formula | C26H32O8 |
| Molecular Weight | 472.527 |
| Flash Point | 242.4±26.4 °C |
| Exact Mass | 472.209717 |
| LogP | 3.81 |
| Vapour Pressure | 0.0±2.5 mmHg at 25°C |
| Index of Refraction | 1.614 |
| InChIKey | YWHHRFNOJTVNBI-LBEFLKDASA-N |
| SMILES | C=C(C)C(CCC(C)(C)O)Cc1c(O)cc(OC)c2c1OC(c1ccc(O)cc1O)C(O)C2=O |
Synonyms
| 4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-2,3-dihydro-3,7-dihydroxy-8-[(2R)-5-hydroxy-5-methyl-2-(1-methylethenyl)hexyl]-5-methoxy-, (2R,3S)- |
| (2R,3S)-2-(2,4-Dihydroxyphenyl)-3,7-dihydroxy-8-[(2R)-5-hydroxy-2-isopropenyl-5-methylhexyl]-5-methoxy-2,3-dihydro-4H-chromen-4-one |
| (2R,3S)-2-(2,4-dihydroxyphenyl)-3,7-dihydroxy-8-[(2R)-5-hydroxy-5-methyl-2-(prop-1-en-2-yl)hexyl]-5-methoxy-2,3-dihydro-4H-chromen-4-one |
