Introduction：Basic information about CAS 1458576-00-5|Biotin-PEG4-alkyne, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Biotin-PEG4-alkyne |
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| CAS Number | 1458576-00-5 | Molecular Weight | 457.58 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C21H35N3O6S | Melting Point | 55-64 °C |
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| MSDS | / | Flash Point | / |
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Names
| Name | Acetylene-PEG4-biotin conjugate |
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Biotin-PEG4-alkyne BiologicalActivity
| Description | Biotin-PEG4-alkyne is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | PEGs |
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| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
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| References | [1]. Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521. |
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Chemical & Physical Properties
| Melting Point | 55-64 °C |
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| Molecular Formula | C21H35N3O6S |
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| Molecular Weight | 457.58 |
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| InChIKey | SKMJWNZZFUDLKQ-DXCJPMOASA-N |
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| SMILES | C#CCOCCOCCOCCOCCNC(=O)CCCCC1SCC2NC(=O)NC21 |
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| Storage condition | -20°C |
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