CAS 28500-04-1|Malvidin-3-O-arabinoside chloride

Introduction：Basic information about CAS 28500-04-1|Malvidin-3-O-arabinoside chloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameMalvidin-3-O-arabinoside chloride
CAS Number28500-04-1Molecular Weight498.864
Density/Boiling Point/
Molecular FormulaC22H23O11.ClMelting Point/
MSDS/Flash Point/

Names

NameMalvidin-3-O-arabinoside chloride
SynonymMore Synonyms

Malvidin-3-O-arabinoside chloride BiologicalActivity

DescriptionMalvidin-3-O-arabinoside chloride ameliorates ethyl carbamate-induced oxidative damage by stimulating AMPK-mediated autophagy[1].
Related CatalogSignaling Pathways >>Epigenetics >>AMPKSignaling Pathways >>Autophagy >>AutophagyResearch Areas >>Inflammation/ImmunologySignaling Pathways >>PI3K/Akt/mTOR >>AMPKResearch Areas >>Metabolic Disease
In VitroMalvidin-3-O-arabinoside chloride (M3A chloride, 50-400 μM) pretreatment remarkably upregulates LAMP-1 expression, which indicates elevated lysosomal mass. M3A also successfully restores lysosomal acidity and subsequently strengthenes lysosomal functions. M3A stimulates phosphorylation of AMP-activated protein kinase (AMPK), a master regulator of autophagy[1]. Cell Autophagy Assay[1] Cell Line: Caco-2 cell line. Concentration: 50, 100, 200 and 400 μM. Incubation Time: 24 h (then treated with or without 10 μM chloroquine (CQ) for another 1 h). Result: Notably inhibited excess ROS generation. 200 μM and 400 μM M3A pretreatment significantly enhanced 14% and 16% of GSH level. Enhanced autophagy flux. Significantly up-regulate the LC3-II/LC3-I ratio.
References

[1]. Yuting Li, et al. Malvidin-3-O-arabinoside ameliorates ethyl carbamate-induced oxidative damage by stimulating AMPK-mediated autophagy. Food Funct. 2020 Dec 1;11(12):10317-10328.

Chemical & Physical Properties

Molecular FormulaC22H23O11.Cl
Molecular Weight498.864
Exact Mass498.092896

Synonyms

5,7-Dihydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)-3-chromeniumyl D-arabinopyranoside chloride
D-Arabinopyranoside, 5,7-dihydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)-1-benzopyrylium-3-yl, chloride (1:1)
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