Introduction：Basic information about CAS 466663-11-6|3-O-(2'E,4'E-Decadienoyl)-ingenol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 3-O-(2'E,4'E-Decadienoyl)-ingenol |
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| CAS Number | 466663-11-6 | Molecular Weight | 498.651 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 635.6±55.0 °C at 760 mmHg |
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| Molecular Formula | C30H42O6 | Melting Point | / |
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| MSDS | / | Flash Point | 201.7±25.0 °C |
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Names
| Name | 3-O-(2'E,4'E-Decadienoyl)ingenol |
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| Synonym | More Synonyms |
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3-O-(2'E,4'E-Decadienoyl)-ingenol BiologicalActivity
| Description | 3-O-(2'E,4'E-Decadienoyl)-ingenol is a natural diterpenoid that shows cytotoxicity against human normal cell lines L-O2 and GES-1, with IC50s of 8.22 μM and 6.67 μM, respectively[1]. |
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| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
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| In Vitro | 3-O-(2'E,4'E-Decadienoyl)-ingenol（5-30 μg/mL；24 小时）显示出对人类正常细胞系 L-O2 和 GES-1 的细胞毒性，具有剂量依赖关系 [1]。 Cell Cytotoxicity Assay[1] Cell Line: L-O2 and GES-1 cells Concentration: 5 μg/mL, 10 μg/mL,15 μg/mL, 20 μg/mL, 25 μg/mL, 30 μg/mL Incubation Time: 24 hours Result: Showed cytotoxicity against human normal cell lines L-O2 and GES-1 with dose-dependent relationships. |
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| References | [1]. Li Zhang, et al. Bio-guided isolation of the cytotoxic terpenoids from the roots of Euphorbia kansui against human normal cell lines L-O2 and GES-1. Int J Mol Sci. 2012;13(9):11247-11259. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 635.6±55.0 °C at 760 mmHg |
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| Molecular Formula | C30H42O6 |
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| Molecular Weight | 498.651 |
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| Flash Point | 201.7±25.0 °C |
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| Exact Mass | 498.298126 |
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| LogP | 7.30 |
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| Vapour Pressure | 0.0±4.2 mmHg at 25°C |
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| Index of Refraction | 1.584 |
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| InChIKey | XMXZQPNIMGCMHC-RIEFUZAHSA-N |
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| SMILES | CCCCCC=CC=CC(=O)OC1C(C)=CC23C(=O)C(C=C(CO)C(O)C12O)C1C(CC3C)C1(C)C |
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Synonyms
| 2,4-Decadienoic acid, (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-1a,2,5,5a,6,9,10,10a-octahydro-5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1H-2,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-6-yl ester, (2E,4E)- |
| (1S,4S,5S,6R,9S,10R,12R,14R)-5,6-Dihydroxy-7-(hydroxymethyl)-3,11,11,14-tetramethyl-15-oxotetracyclo[7.5.1.01,5.010,12]pentadeca-2,7-dien-4-yl (2E,4E)-2,4-decadienoate |
