Introduction：Basic information about CAS 629167-92-6|Mipomersen sodium, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Mipomersen sodium |
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| CAS Number | 629167-92-6 | Molecular Weight | / |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C230H305N67Na19O122P19S19 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | MipoMersen sodiuM |
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| Synonym | More Synonyms |
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Mipomersen sodium BiologicalActivity
| Description | Mipomersen (sodium) is a second-generation 20-base phosphorothioate ASO targeted to human apoB-100[1][2]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease |
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| In Vitro | Mipomersen predominantly distributes to the liver and decreases the production of apoB-100, the primary structural protein of the atherogenic lipoproteins including low density lipoprotein (LDL), thereby reducing plasma LDL-cholesterol and apoB-100 concentrations[2]. Apolipoprotein (apo) B, a large amphipathic protein, plays a fundamental role in human lipoprotein metabolism. ApoB-100 is also a ligand for LDL receptor-mediated endocytosis of LDL by cells[2]. |
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| References | [1]. Philip Hair, et al. Mipomersen sodium: first global approval. Drugs. 2013 Apr;73(5):487-93. [2]. Damon A Bell, et al. Mipomersen, an antisense apolipoprotein B synthesis inhibitor. Expert Opin Investig Drugs. 2011 Feb;20(2):265-72. |
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Chemical & Physical Properties
| Molecular Formula | C230H305N67Na19O122P19S19 |
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Synonyms
