(-)-ISOPROTERENOL HYDROCHLORIDE CAS 5984-95-2

Introduction：Basic information about (-)-ISOPROTERENOL HYDROCHLORIDE CAS 5984-95-2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

(-)-ISOPROTERENOL HYDROCHLORIDE Basic information

• Product Name: (-)-ISOPROTERENOL HYDROCHLORIDE
• Synonyms: (r)-isoprenalinehydrochloride;isopropylnoradrenaline;isoprotemol;(-)-N-ISOPROPYL-L-NORADRENALIN HYDROCHLO RIDE;Off-whitecrystalsHCl;1,2-Benzenediol, 4-[(1R)-1-hydroxy-2-[(1-methylethyl)amino]ethyl]-, hydrochloride (9CI);1,2-Benzenediol, 4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]-, hydrochloride, (R)-;Benzyl alcohol, 3,4-dihydroxy-a-[(isopropylamino)methyl]-, hydrochloride, (-)- (8CI)
• CAS: 5984-95-2
• MF: C11H18ClNO3
• MW: 247.72
• Mol File: 5984-95-2.mol

(-)-ISOPROTERENOL HYDROCHLORIDE Chemical Properties

• Melting point: 175 °C (dec.)(lit.)
• storage temp.: −20°C
• solubility: soluble (50 mg/ml: H₂O)
• form: Solid
• color: White to off-white
• Water Solubility: soluble (50 mg/ml: H2O)
• BRN: 6077193
• InChI: InChI=1S/C11H17NO3.ClH/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8;/h3-5,7,11-15H,6H2,1-2H3;1H
• InChIKey: IROWCYIEJAOFOW-UHFFFAOYSA-N
• SMILES: CC(C)NCC(O)C1C=CC(O)=C(O)C=1.[H]Cl
• CAS DataBase Reference: 5984-95-2(CAS DataBase Reference)

Safety Information

• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: DO1926000
• F: 10
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

(-)-ISOPROTERENOL HYDROCHLORIDE Usage And Synthesis

Uses

(-)-Isoproterenol hydrochloride is a non-selective beta-adrenergic agonist. Isoproterenol is used in the treatment of bradycardia; bronchodilator.

Biochem/physiol Actions

Isoproterenol hydrochloride is useful in post transplantal organ recovery. It exhibits ionotropic and chronotropic effects. With respect to donor heart recovery, isoproterenol hydrochloride decreases peripheral and systemic vascular resistance. Isoproterenol also increases the heart rate.

in vivo

(-)-Isoproterenol hydrochloride (85 mg/kg; s.c.; daily for two consecutive days) induces ventricular remodeling (VR) in rat^[1].

• Animal Model: 180-200 g, 6-7 weeks, Healthy male Sprague Dawley rats^[1]
• Dosage: 85 mg/kg
• Administration: S.c.; daily for two consecutive days
• Result: Decreased the systolic blood pressure (SBP) levels, increased LV weight index (LVWI) and heart weight index (HWI), the average cross section area markedly increased, significant increased in the levels of NT-proBNP in the myocardium.