Introduction：Basic information about (2-Chloro-3-pyridinyl)methanol CAS 42330-59-6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
(2-Chloro-3-pyridinyl)methanol Basic information
| Product Name: | (2-Chloro-3-pyridinyl)methanol |
| Synonyms: | (2-CHLORO-PYRIDIN-3-YL)-METHANOL;(2-CHLORO-3-PYRIDINYL)METHANOL;2-CHLORO-3-(HYDROXYMETHYL)PYRIDINE;2-Chloro-3-(hydroxymethyl)pyridine 97%;2-Chloro-3-pyridinemethanol;2-Chloro-3-(hydroxymethyl...;2-Chloropyridine-3-Methanol;(2-Chloropyridin-3-yl)methanol, 2-Chloronicotinyl alcohol |
| CAS: | 42330-59-6 |
| MF: | C6H6ClNO |
| MW: | 143.57 |
| EINECS: | 205-516-1 |
| Product Categories: | pharmacetical;Hydroxymethyl's;Pyridine;Alcohols and Derivatives;Heterocycles;Pyridines |
| Mol File: | 42330-59-6.mol |
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(2-Chloro-3-pyridinyl)methanol Chemical Properties
| Melting point | 54 °C |
| Boiling point | 112℃/0.2mm |
| density | 1.324±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | soluble in Methanol |
| form | Solid |
| pka | 13.00±0.10(Predicted) |
| color | White to Gray to Brown |
| InChI | InChI=1S/C6H6ClNO/c7-6-5(4-9)2-1-3-8-6/h1-3,9H,4H2 |
| InChIKey | HMPDWSBKPCOQDW-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC=CC=C1CO |
| CAS DataBase Reference | 42330-59-6(CAS DataBase Reference) |
Safety Information
| Hazard Codes | Xn,T |
| Risk Statements | 20/21/22-36/37/38-52/53-23/24/25 |
| Safety Statements | 22-26-36/37/39-61-45-36/37 |
| RIDADR | UN2811 |
| Hazard Note | Harmful |
| HazardClass | IRRITANT |
| HS Code | 2933399990 |
(2-Chloro-3-pyridinyl)methanol Usage And Synthesis
| Chemical Properties | Light yellow needles |
| Synthesis | 2-Chloro-3-chloromethyl pyridine 162.8 g (content 99.5%) was added to 270 g of water, 200 g of sodium acetate was added, heated to reflux, the reflux temperature was controlled at 110 ?? C, and the reaction was carried out for 10 h. After removing the water, as well as the sodium acetate, and the sodium chloride, 2-chloro-3-pyridine acetic acid methyl ester was obtained as 171.9 g, with a purity of 99%. Hydrolyzed methyl 2-chloro-3-pyridineacetate in 15% sodium hydroxide solution 300 ml at 25??C for 10 hours, and removed the sodium hydroxide aqueous solution to obtain 2-chloro-3-pyridinemethanol 142.5g. |
(2-Chloro-3-pyridinyl)methanol Preparation Products And Raw materials
| Raw materials | Ethyl 2-chloronicotinate-->2-Chloro-3-pyridinecarboxaldehyde-->2-Chloronicotinic acid |
| Preparation Products | 2-BROMO-3-(CHLOROMETHYL)PYRIDINE-->Voxelotor |
