Introduction：Basic information about (2S,5R)-2-(2-acetylhydrazine-1-carbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate CA, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
(2S,5R)-2-(2-acetylhydrazine-1-carbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate Basic information
| Product Name: | (2S,5R)-2-(2-acetylhydrazine-1-carbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate |
| Synonyms: | (2S,5R)-2-(2-acetylhydrazine-1-carbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate;1,6-Diazabicyclo[3.2.1]octane-2-carboxylic acid, 7-oxo-6-(sulfooxy)-, 2-(2-acetylhydrazide), (1R,2S,5R)- |
| CAS: | 1452459-50-5 |
| MF: | C9H14N4O7S |
| MW: | 322.29 |
| EINECS: | |
| Product Categories: | |
| Mol File: | 1452459-50-5.mol |
|
(2S,5R)-2-(2-acetylhydrazine-1-carbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate Chemical Properties
| density | 1.74±0.1 g/cm3(Predicted) |
| pka | -4.59±0.18(Predicted) |
Safety Information
(2S,5R)-2-(2-acetylhydrazine-1-carbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate Usage And Synthesis
| Uses | FPI-1523, a derivative of Avibactam, is a potent β-lactamase inhibitor, with Kds of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. FPI-1523 also inhibits PBP2, with an IC50 of 3.2 μM. FPI-1523 exhibits considerable antimicrobial activity[1]. |
| References | [1] King AM, et, al. Structural and Kinetic Characterization of Diazabicyclooctanes as Dual Inhibitors of Both Serine-β-Lactamases and Penicillin-Binding Proteins. ACS Chem Biol. 2016 Apr 15;11(4):864-8. DOI:10.1021/acschembio.5b00944 |
(2S,5R)-2-(2-acetylhydrazine-1-carbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate Preparation Products And Raw materials
