(4-Carboxybutyl)triphenylphosphonium bromide CAS 17814-85-6
Introduction：Basic information about (4-Carboxybutyl)triphenylphosphonium bromide CAS 17814-85-6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
(4-Carboxybutyl)triphenylphosphonium bromide Basic information
| Product Name: | (4-Carboxybutyl)triphenylphosphonium bromide |
| Synonyms: | (4-CARBOXYBUTYL)TRIPHENYLPHOSPHONIUM BROMIDE;(4-Carboxybutyl)triphenylphosp;PhosphoniuM,(4-carboxybutyl)triphenyl-, broMide (1:1);4-carboxybutyltripheyl phosphonium bromide;(4-(4-carboxybutyl)phenyl)diphenylphosphonium bromide;4-carboxybutyl(triphenyl)phosphanium,bromide;(4-Carboxybut;(4-Carboxybut-1-yl)(triphenyl)phosphonium bromide 98% |
| CAS: | 17814-85-6 |
| MF: | C23H24BrO2P |
| MW: | 443.31 |
| EINECS: | 241-782-5 |
| Product Categories: | Miscellaneous Reagents;API intermediates;Miscellaneous Compounds;Phosphonium Compounds;Synthetic Organic Chemistry;Wittig & Horner-Emmons Reaction;Wittig Reaction;C-C Bond Formation;Olefination;Wittig Reagents |
| Mol File: | 17814-85-6.mol |
(4-Carboxybutyl)triphenylphosphonium bromide Chemical Properties
| Melting point | 204-207 °C(lit.) |
| Boiling point | 324.7-327.4℃ at 101.93-102.15kPa |
| bulk density | 360-400kg/m3 |
| density | 1.371 at 20℃ |
| vapor pressure | 0Pa at 25℃ |
| Fp | 195°(383°F) |
| storage temp. | Store below +30°C. |
| solubility | DMSO, Methanol, Water |
| form | solid |
| color | White to Off-White |
| Water Solubility | Soluble in ethanol, methanol and soluble water. Insoluble in toluene and hexane. |
| Sensitive | Hygroscopic |
| BRN | 3586477 |
| InChI | 1S/C23H23O2P.BrH/c24-23(25)18-10-11-19-26(20-12-4-1-5-13-20,21-14-6-2-7-15-21)22-16-8-3-9-17-22;/h1-9,12-17H,10-11,18-19H2;1H |
| InChIKey | KQJPHSBFOSLICV-UHFFFAOYSA-N |
| SMILES | [Br-].OC(=O)CCCC[P+](c1ccccc1)(c2ccccc2)c3ccccc3 |
| LogP | 0.146 |
| CAS DataBase Reference | 17814-85-6(CAS DataBase Reference) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | 3278 |
| WGK Germany | 3 |
| HS Code | 29310095 |
| Storage Class | 6.1D - Non-combustible acute toxic Cat.3 toxic hazardous materials or hazardous materials causing chronic effects |
| Hazard Classifications | Acute Tox. 3 Oral Eye Dam. 1 |
| Chemical Properties | WHITE TO ALMOST WHITE CRYSTALLINE POWDER |
| Uses | suzuki reaction |
| Uses | (4-Carboxybutyl)triphenylphosphonium Bromide (cas# 17814-85-6) is a compound useful in organic synthesis. |
| Uses |
Reactant for preparation of:
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| reaction suitability | reaction type: C-C Bond Formation |
| Synthesis | 2067-33-6 603-35-0 17814-85-6 General method: 5-Bromovaleric acid (1 eq.) and triphenylphosphine (1 eq.) were dissolved in 300 mL of toluene and the reaction was refluxed under argon protection for 48 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated under reduced pressure. The target product 4-carboxybutyltriphenylphosphonium bromide was obtained by crystallization and purification of the residue from a suitable solvent. |
| References | [1] Journal of Organic Chemistry, 1999, vol. 64, # 9, p. 3196 - 3206 [2] Canadian Journal of Chemistry, 2003, vol. 81, # 6, p. 697 - 704 [3] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 1, p. 567 - 579 [4] Journal of Organic Chemistry, 1987, vol. 52, # 20, p. 4449 - 4453 [5] Journal of Medicinal Chemistry, 2017, vol. 60, # 14, p. 6353 - 6363 |
(4-Carboxybutyl)triphenylphosphonium bromide Preparation Products And Raw materials
| Raw materials | 5-Bromovaleric acid-->Triphenylphosphine |
| Preparation Products | 6-PHENYL-1-HEXANOL-->(+)-Fluprostenol-->(+)-Cloprostenol-->5-cyclopentylpentanoic acid |
