Introduction：Basic information about CAS 64987-82-2|N-(4-Carboxycyclohexylmethyl)maleimide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | N-(4-Carboxycyclohexylmethyl)maleimide |
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| CAS Number | 64987-82-2 | Molecular Weight | 237.252 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 433.6±18.0 °C at 760 mmHg |
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| Molecular Formula | C12H15NO4 | Melting Point | 157-158ºC |
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| MSDS | / | Flash Point | 216.0±21.2 °C |
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Names
| Name | N-[4-(-Carboxycyclohexylmethyl)]maleimide |
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| Synonym | More Synonyms |
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N-(4-Carboxycyclohexylmethyl)maleimide BiologicalActivity
| Description | N-(4-Carboxycyclohexylmethyl)maleimide is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | Alkyl-Chain |
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| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
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| References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 433.6±18.0 °C at 760 mmHg |
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| Melting Point | 157-158ºC |
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| Molecular Formula | C12H15NO4 |
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| Molecular Weight | 237.252 |
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| Flash Point | 216.0±21.2 °C |
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| Exact Mass | 237.100113 |
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| PSA | 74.68000 |
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| LogP | 1.13 |
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| Vapour Pressure | 0.0±2.2 mmHg at 25°C |
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| Index of Refraction | 1.568 |
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| InChIKey | LQILVUYCDHSGEU-UHFFFAOYSA-N |
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| SMILES | O=C(O)C1CCC(CN2C(=O)C=CC2=O)CC1 |
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| Storage condition | -20°C |
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Safety Information
Customs
| HS Code | 2925190090 |
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| Summary | 2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
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Synonyms
| Cyclohexanecarboxylic acid, 4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]- |
| 4-[(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl]cyclohexanecarboxylic acid |
