(R)-(-)-1-Cyclohexylethylamine CAS 5913-13-3

Introduction：Basic information about (R)-(-)-1-Cyclohexylethylamine CAS 5913-13-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

(R)-(-)-1-Cyclohexylethylamine Basic information

• Product Name: (R)-(-)-1-Cyclohexylethylamine
• Synonyms: (R)-(-)-1-Cyclohexylethylamine;R(-)-ALPHA-METHYLCYCLOHEXANEMETHYLAMINE;(R)-(-)-1-CYCLOHEXYLETHYLAMINE;(R)-1-CYCLOHEXYLETHYLAMINE;Cyclohexanemethanamine, alpha-methyl-, (R)-;(R)-alpha-cyclohexanemethylamine;(R)-(-)-1-CYCLOHEXYLETHYLAMINE 98%;(r)-(-)-à-methylcyclohexanemethylamine
• CAS: 5913-13-3
• MF: C8H17N
• MW: 127.23
• EINECS: 227-634-2
• Product Categories: Amines (Chiral);Chiral Building Blocks;Synthetic Organic Chemistry
• Mol File: 5913-13-3.mol

(R)-(-)-1-Cyclohexylethylamine Chemical Properties

• Melting point: -15°C (estimate)
• alpha: -3.8 º (NEAT)
• Boiling point: 177-178 °C (lit.)
• density: 0.866 g/mL at 20 °C (lit.)
• refractive index: n20/D 1.463
• Fp: 126 °F
• storage temp.: 2-8°C, protect from light
• pka: 10.89±0.29(Predicted)
• form: clear liquid
• color: Colorless to Almost colorless
• Optical Rotation: [α]20/D 4°, neat &_& [α]20/D -3.8±0.3°, neat
• Water Solubility: Miscible with acetone, chloroform,dimethyl sulfoxide, ethanol, methanol, ether, petroleum ether and dichloromethane. Insoluble in water.
• Sensitive: Air Sensitive
• BRN: 2935070
• InChI: 1S/C8H17N/c1-7(9)8-5-3-2-4-6-8/h7-8H,2-6,9H2,1H3/t7-/m1/s1
• InChIKey: XBWOPGDJMAJJDG-SSDOTTSWSA-N
• SMILES: C[C@@H](N)C1CCCCC1
• CAS DataBase Reference: 5913-13-3(CAS DataBase Reference)
• NIST Chemistry Reference: R-(-)-Cyclohexylethylamine(5913-13-3)

Safety Information

• Hazard Codes: C
• Risk Statements: 10-21/22-34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2734 8/PG 2
• WGK Germany: 3
• F: 3-10-23
• HazardClass: 8
• PackingGroup: II
• HS Code: 2921309990
• Storage Class: 3 - Flammable liquids
• Hazard Classifications: Acute Tox. 4 Oral Flam. Liq. 3 Skin Corr. 1B

(R)-(-)-1-Cyclohexylethylamine Usage And Synthesis

Chemical Properties

optical purity >99% ee

Uses

(R)-(-)-1-Cyclohexylethylamine is used in the preparation of benzylidene(1-cyclohexylethyl)amine by reacting with benzaldehyde. It is also used to prepare chiral polymethacrylamides, which are employed as stationary phases for the liquid-chromatographic resolution of racemic amides. In addition to this, it is used in the preparation of polyamides bound to silica gel for high performance liquid chromatography, which are pressure-stable.

Uses

(R)-(-)-1-Cyclohexylethylamine may be used in the preparation of a chiral calix[4]arene Schiff base derivatives with potential enantioselective recognition ability towards amines.

General Description

(R)-(-)-1-Cyclohexylethylamine is a chiral amine mainly used as a resolving agent for racemic compounds.

Purification Methods

Purify it by conversion to the bitartrate salt (m 172o), then decomposing with strong alkali and extracting into Et2O, drying (KOH), filtering, evaporating and distilling. The hydrochloride salt has m 242o (from EtOH/Et2O), [] D -5.0o (c 10 H2O, from (+) amine). The oxalate salt has m 132o (from H2O). The (±)-base has b 176-178o/760mm, and HCl has m 237-238o. [Reihlen et al. Justus Liebigs Ann Chem 532 247 1938, Leithe Chem Ber 65 660 1932, Beilstein 12 III 95.]