(S)-Flurbiprofen CAS 51543-39-6

Introduction：Basic information about (S)-Flurbiprofen CAS 51543-39-6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

(S)-Flurbiprofen Basic information

• Product Name: (S)-Flurbiprofen
• Synonyms: (S)-(+)-FLURBIPROFEN;(S)-FLURBIPROFEN;(S)-(+)-2-FLUORO-ALPHA-METHYL-4-BIPHENYLACETIC ACID;Esflurbiprofen;(S)-2-fluoro-alpha-methyl[1,1'-biphenyl]-4-acetic acid;(S)-(+)-2-Fluoro-α-methyl-4-biphenylacetic acid;[1,1'-Biphenyl]-4-acetic acid, 2-fluoro-α-methyl-, (S)-;[1,1'-Biphenyl]-4-acetic acid, 2-fluoro-α-methyl-, (αS)-
• CAS: 51543-39-6
• MF: C15H13FO2
• MW: 244.26
• EINECS: 257-263-1
• Mol File: 51543-39-6.mol

(S)-Flurbiprofen Chemical Properties

• Melting point: 109-110 °C(lit.)
• Boiling point: 376.2±30.0 °C(Predicted)
• density: 1.199±0.06 g/cm3(Predicted)
• storage temp.: Sealed in dry,Room Temperature
• solubility: insoluble in H2O; ≥10.9 mg/mL in DMSO; ≥69.1 mg/mL in EtOH
• form: A crystalline solid
• pka: 4.14±0.10(Predicted)
• color: White to off-white
• InChI: InChI=1/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)/t10-/s3
• InChIKey: SYTBZMRGLBWNTM-JQHDBZEONA-N
• SMILES: C1(=CC=C([C@H](C)C(=O)O)C=C1F)C1=CC=CC=C1 |&1:4,r|

Safety Information

• Hazard Codes: T
• Risk Statements: 25
• Safety Statements: 36/37/39-45
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3

(S)-Flurbiprofen Usage And Synthesis

Description

Marketed by TaishoPharmaceutical Holdings Co., Ltd., and Teijin Pharma Ltd.,the (S)-enantiomer of flurbiprofen (named Esflurbiprofen) wasapproved as a new drug by the PMDA of Japan in 2015. (S)-Flurbiprofen, a cyclooxygenase (COX)-inhibiting nonsteroidalanti-inflammatory (NSAID) drug, is formulated with menthaoil and administered by way of a patch as a treatment forosteoarthritis in the current invention. Interestingly, the (R)-enantiomer is responsible for minimal COX inhibition but hasbeen implicated as a possible treatment for a variety of otherdiseases. Synthetic approaches to racemic flurbiprofen have been reported in the chemical literature as early as the 1960s,and the mixture was approved as a drug in the United States bythe FDA in 1988, marketed by Pharmacia and Upjohn.Toward this end, the current patent estate defines the utility ofthe active S-enantiomer, and synthetic approaches therein applyto this enantiomer only.

Description

(S)-Flurbiprofen is the COX-active enantiomer of the non-selective COX inhibitor flurbiprofen with IC₅₀ values of 0.48 and 0.47 μM for COX-1 and COX-2, respectively, in guinea pig whole blood. It inhibits the release of 6-keto prostaglandin F_1α (6-keto-PGF_1α; ) and thromboxane B₂ (TXB₂; ) from rat whole blood, gastric mucosa, lung, and jejunal tissue ex vivo in a dose-dependent manner. (S)-Flurbiprofen (1 nM) inhibits basal and bradykinin-, serotonin-, and histamine-stimulated prostaglandin E₂ (PGE₂) release from isolated skin flaps of rat lower hind paws. It also inhibits release of the neuroinflammatory marker calcitonin gene-related peptide (CGRP; Item Nos. 24405 | 24725 | 24728) when used at a concentration of 1 μM. In vivo, (S)-flurbiprofen reduces the number of flinches per minute in the formalin test in rats, indicating antinociceptive activity.

Uses

(S)-Flurbiprofen is the S-isomer of Flurbiprofen (F598700), an anti-inflammatory used as an analgesic.

Definition

ChEBI: (S)-flurbiprofen is a flurbiprofen. It is an enantiomer of a (R)-flurbiprofen.

Synthesis

The synthesis began with conversion of commerciallyavailable aniline 168 to racemic flurbiprofen (169) through a Sandmeyer reaction and subsequent phenylgroup introduction through the use of sodium tetraphenylborate. A chiral resolution was then performed on the resultingstereogenic acid on multikilogram scale by treatment with (S)-1-phenylethylamine in MeOH/toluene, which gave variousyields of salt 170 as reported by the authors. Acidificationwith aqueous HCl delivered (S)-flurbiprofen (XXI). Importantly,with respect to green chemistry considerations, the (R)-enantiomer could be recycled by racemizing the undesired (R)-enantiomer 171 in refluxing methanolic sulfuric acid, improvingthe overall atom economy of the process and significantlyreducing waste.

in vitro

it was found that the ic50 value of (s)-flurbiprofen was about 0.5 μm for both cox-1 and cox-2 in guinea pig whole blood [1].

in vivo

the efficacy of multiple applications of s(+)-flurbiprofen plaster (sfpp) was evaluated for the alleviation of inflammatory pain and edema in rat adjuvant-induced arthritis model. multiple applications of sfpp could exert a significant analgesic effect from the first day of application as compared to the other nsaid drugs. in terms of paw edema, sfpp could decrease edema from the second day after application. moreover, multiple applications of sfpp were found to be superior to those of other nsaid drugs in terms of the analgesic effect [2].

IC 50

0.5 μm for both cox-1 and cox-2 in guinea pig whole blood

references

[1] barnett, j. ,chow, j.,ives, d., et al. purification, characterization and selective inhibition of human prostaglandin g/h synthase 1 and 2 expressed in the baculovirus system. biochimica et biophysica acta 1209, 130-139 (1994).
[2] sugimoto m et al. topical anti-inflammatory and analgesic effects of multiple applications of s(+)-flurbiprofen plaster (sfpp) in a rat adjuvant-induced arthritis model. drug dev res. 2016 jun;77(4):206-11.
[3] yataba i, otsuka n, matsushita i, matsumoto h, hoshino y. the efficacy and safety of s-flurbiprofen plaster in the treatment of knee osteoarthritis: a phase ii, randomized, double-blind, placebo-controlled, dose-finding study. j pain res. 2017 apr 11;10:867-880.