1-(4-Hydroxy-2-Methoxyphenyl) -3-(4-hydroxy-3-prenylphenyl)propane CAS 376362-03-7

Introduction：Basic information about 1-(4-Hydroxy-2-Methoxyphenyl) -3-(4-hydroxy-3-prenylphenyl)propane CAS 376362-03-7, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

1-(4-Hydroxy-2-Methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl)propane Basic information

• Product Name: 1-(4-Hydroxy-2-Methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl)propane
• Synonyms: 1-(4-Hydroxy-2-Methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl)propane;4-(3-(4-Hydroxy-2-Methoxyphenyl)propyl)-2-(3-Methylbut-2-en-1-yl)phenol;2'-O-Methylbroussonin C;Phenol, 4-[3-(4-hydroxy-2-methoxyphenyl)propyl]-2-(3-methyl-2-buten-1-yl)-
• CAS: 376362-03-7
• MF: C21H26O3
• MW: 326.42934
• Mol File: 376362-03-7.mol

1-(4-Hydroxy-2-Methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl)propane Chemical Properties

• Melting point: 85-86 °C
• Boiling point: 490.3±40.0 °C(Predicted)
• density: 1.102±0.06 g/cm3(Predicted)
• solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
• form: Powder
• pka: 9.78±0.20(Predicted)

1-(4-Hydroxy-2-Methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl)propane Usage And Synthesis

Uses

1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl), isolated from Broussonetia kazinoki, shows in vitro inhibition of protein tyrosine phosphatase 1B (PTP1B) with an IC50 of 13.00 μM. PTP1B is a negative regulator of insulin action and an important mediator in the pathogenesis of insulinresistance and non-insulin dependent diabetes mellitus. PTP1B is regarded as a significant target for type 2 diabetes[1].

References

[1] Jing-Jing Xue, et al. Flavans and diphenylpropanes with PTP1B inhibition from Broussonetia kazinoki. Fitoterapia. 2018 Oct;130:37-42. DOI:10.1016/j.fitote.2018.08.001