1,1-Dimethylhydrazine CAS 57-14-7
Introduction：Basic information about 1,1-Dimethylhydrazine CAS 57-14-7, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
1,1-Dimethylhydrazine Basic information
| Product Name: | 1,1-Dimethylhydrazine |
| Synonyms: | Niesymetryczna dwu metylohydrazyna;niesymetrycznadwumetylohydrazyna;niesymetrycznadwumetylohydrazyna(polish);Rcra waste number U098;rcrawastenumberu098;u-Dimethylhydrazine;uns-Dimethylhydrazine;Unsymmetrical dimethylhydrazine |
| CAS: | 57-14-7 |
| MF: | C2H8N2 |
| MW: | 60.1 |
| EINECS: | 200-316-0 |
| Product Categories: | organic compound;Building Blocks;Chemical Synthesis;Hydrazines;Nitrogen Compounds;Organic Building Blocks |
| Mol File: | 57-14-7.mol |
1,1-Dimethylhydrazine Chemical Properties
| Melting point | -57.2 °C |
| Boiling point | 60-62 °C(lit.) |
| density | 0.79 g/mL at 20 °C(lit.) |
| vapor density | 1.94 (vs air) |
| vapor pressure | 103 mm Hg ( 20 °C) |
| refractive index | n |
| Fp | 34 °F |
| storage temp. | 2-8°C |
| solubility | Miscible with alcohol, N,N-dimethylformamide, ether, hydrocarbons (Windholz et al., 1983), andmany other polar solvents. |
| form | Colorless liquid |
| pka | 8.19±0.18(Predicted) |
| explosive limit | 95% |
| Water Solubility | miscible |
| Sensitive | Hygroscopic |
| Merck | 14,3247 |
| BRN | 605261 |
| Henry's Law Constant | 2.45(x 10-9 atm?m3/mol) at 25 °C (quoted, Mercer et al., 1990) |
| Exposure limits | TLV-TWA skin 0.5 ppm (1.0 mg/m3 )(ACGIH, MSHA, and OSHA); carcinogenicity:Animal Sufficient Evidence (IARC), Suspected Carcinogen (ACGIH). |
| CAS DataBase Reference | 57-14-7(CAS DataBase Reference) |
| IARC | 2B (Vol. 4, Sup 7, 71) 1999 |
| NIST Chemistry Reference | Hydrazine, 1,1-dimethyl-(57-14-7) |
| EPA Substance Registry System | 1,1-Dimethylhydrazine (57-14-7) |
Safety Information
| Hazard Codes | F,T,N |
| Risk Statements | 45-11-23/25-34-51/53-37-23/24/25 |
| Safety Statements | 53-45-61-36/37 |
| RIDADR | UN 1163 6.1/PG 1 |
| OEL | Ceiling: 0.06 ppm (0.15 mg/m3) [2-hr] |
| WGK Germany | 3 |
| RTECS | MV2450000 |
| Autoignition Temperature | 478 °F |
| TSCA | TSCA listed |
| HazardClass | 6.1 |
| PackingGroup | I |
| HS Code | 29280090 |
| Storage Class | 3 - Flammable liquids |
| Hazard Classifications | Acute Tox. 3 Dermal Acute Tox. 3 Inhalation Acute Tox. 3 Oral Aquatic Chronic 2 Carc. 1B Eye Dam. 1 Flam. Liq. 2 Skin Corr. 1B STOT SE 3 |
| Hazardous Substances Data | 57-14-7(Hazardous Substances Data) |
| Toxicity | Acute oral LD50 for rats 122 mg/kg, mice 265 mg/kg (quoted, RTECS, 1985). |
| IDLA | 15 ppm |
| Description | UDMH is a fuming colorless liquid that turnsyellow on contact with air, with a fishy, amine-like odor.The odor threshold is 6.114 ppm. Molecularweight= 60.12; Boiling point = 63.9℃; Freezing/Meltingpoint = 257.7℃; Vapor pressure= 103 mmHg at 20℃;Flash point = 215℃; Autoignition temperature= 249℃.Explosive limits: LEL = 2.0%; UEL= 95%. HazardIdentification (based on NFPA-704 M Rating System):Health 4, Flammability 3, Reactivity 1. Highly soluble inwater. |
| Chemical Properties | 1,1-Dimethylhydrazine is a colorless, flammable, hygroscopic liquid that gradually turnsyellow on contact with air and is miscible with water. 1,1-Dimethylhydrazine is primar-ily used as a high-energy fuel in military applications, as a rocket propellant and fuel forthrusters, and small electrical power-generating units. 1,1-Dimethylhydrazine is also usedin the manufacture of a plant growth regulator, in chemical synthesis, in photographicchemicals, as a stabilizer for fuel additives, and as an absorbent for acid gases. Exposureto 1,1-dimethylhydrazine usually occurs at the workplace during use and handling of thechemical substance.No information is available on the carcinogenic effects of 1,1-dimethylhydrazine in humans.Carcinogenic effects were observed in mice and rats exposed to 1,1-dimethylhydrazineby inhalation, but the carcinogenicity could not be defi nitively attributed to1,1-dimethylhydrazine because of the presence of contaminants in the study. The US EPAhas not classifi ed 1,1-dimethylhydrazine for potential carcinogenicity, while the IARC hasclassifi ed 1,1-dimethylhydrazine as Group 2B, meaning a possible human carcinogen. |
| Physical properties | Clear, colorless fuming liquid with an amine-like odor. Turns yellow on exposure to air. Odordetection threshold concentrations ranged from 6.1 to 14 ppmv (Jacobson et al., 1955). |
| Uses | 1,1-Dimethylhydrazine is used in rocket fuel. |
| Uses | Base in rocket fuel formulations; intermediatein organic synthesis |
| Uses | N,N-Dimethylhydrazine is used as a reagent in the synthesis of novel substituted pyridinylbenzenesulfonamide derivatives which have herbicidal activity. N,N-Dimethylhydrazine is also used in the preparation of the antibacterial agent, (-)-Platencin. |
| Definition | ChEBI: A member of the class of hydrazines that is hydrazine substituted by two methyl groups at position 1. |
| General Description | A clear colorless liquid with an ammonia-like odor. Flash point 0°F. Corrosive to the skin. Less dense than water and soluble in water. Vapors are heavier than air and very toxic by inhalation, attacking the eyes and respiratory system. Prolonged exposure of containers to heat may result in their violent rupturing and rocketing due to decomposition. Generates toxic oxides of nitrogen when burned. Vapors may travel to a source of ignition and a flame can flashback to the source of vapors. Used as a rocket propellant and to make other chemicals. |
| Air & Water Reactions | Highly flammable over a wide range of vapor concentrations. May ignite spontaneously when spread on a large surface exposed to the air. [Def. Res. and Eng., pp 299-300(1963)]. Dissolves and slowly decomposes in water. |
| Reactivity Profile | 1,1-Dimethylhydrazine is a powerful reducing agent. Ignition can occur on contact with oxidizing agents such hydrogen peroxide and fuming nitric acid, [Haz. Chem. Data(1966)]. Also reacts as a base to neutralize acids in exothermic reactions. |
| Health Hazard | 1,1-Dimethylhydrazine exhibits high acute toxicity as a result of exposure by all routes. Death or permanent injury may result after very short exposure to small quantities. Chronic exposure may cause pneumonia, liver damage, and kidney damage. |
| Health Hazard | The vapors of this compound are irritating tothe eyes, nose, and throat. The liquid is corrosive to the skin. The toxic properties aresimilar to those of 1,1-dimethylhydrazine.Exposure to 280 ppm for 4 hours was fatalto rats. The oral LD50 value in th. |
| Fire Hazard | Vapor may explode if ignited in an enclosed area. Vapors may travel to a source of ignition and flashback. Runoff to sewer may create fire or explosion hazard. When 1,1-Dimethylhydrazine decomposes, 1,1-Dimethylhydrazine gives off toxic nitrogen compound fumes. Dissolves, swells, and disintegrates many plastics. Dangerous when exposed to heat, flame, or oxidizers. Hazardous polymerization may not occur. |
| Safety Profile | Confirmed carcinogen with experimental carcinogenic, tumorigenic, and teratogenic data. Other experimental reproductive effects. Poison byingestion, intraperitoneal, intravenous, and intracerebral routes. Moderately toxic by inhalation and skin contact. Human mutation data reported. A plant growth control agent. Corrosive. A powerful reducing agent. A dangerous fire hazard. It is hypergolic with many oxidants (e.g., dinitrogen tetroxide, hydrogen peroxide, and nitric acid). Dangerous when exposed to heat, flame, or oxidizers; can react vigorously with oxidning materials such as air, fuming HNO3, (HNO3 + N2O4), NO. A high-energy propellant for liquid-fueled rockets. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits highly toxic fumes of NOx. See also HYDRAZINE. |
| Potential Exposure | Tumorigen,Mutagen; Reproductive Effector; Human Data. This material is used as a component in liquid rocket propellant combinations; it is also used in photography; as an absorbent;and to make other chemicals. |
| First aid | If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. If victim is conscious, administer water ormilk. Do not induce vomiting. Medical observation isrecommended for 2448 h after breathing overexposure, aspulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consideradministering a corticosteroid spray. |
| Carcinogenicity | 1,1-Dimethylhydrazine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals. |
| Environmental fate | Chemical/Physical. Releases toxic nitrogen oxides when heated to decomposition (Sax andLewis, 1987). Ignites spontaneously in air or in contact with hydrogen peroxide, nitric acid, orother oxidizers (Patnaik, 1992). N-Nitrosodimethylamine was the major product of ozonation of 1,1-dimethylhydrazine in thedark. Hydrogen peroxide, methyl hydroperoxide, and methyl diazene were also identified (HSDB,1989). |
| storage | (1) Color Code—Red: Flammability Hazard: Storein a flammable liquid storage area or approved cabinetaway from ignition sources and corrosive and reactivematerials. (2) Color Code—Yellow Stripe (strong reducingagent): Reactivity Hazard; Store separately in an area isolated from flammables, combustibles, or other yellow-codedmaterials. (3) Color Code—Blue: Health Hazard/Poison:Store in a secure poison location. Prior to working withUDMH you should be trained on its proper handling andstorage. Outside or detached storage is preferred. Beforeentering confined space where this chemical may be present, check to make sure that an explosive concentrationdoes not exist. Store in tightly closed containers in a cool,well-ventilated area. Keep dry and separate from porousmaterials, oxidizing agents, and other incompatible materials, some of which are listed above. Store in an inert atmosphere below 50℃. Do not use copper containers. Metalcontainers involving the transfer of this chemical should begrounded and bonded. Where possible, automatically pumpliquid from drums or other storage containers to processcontainers. Drums must be equipped with self-closingvalves, pressure vacuum bungs, and flame arresters. Useonly nonsparking tools and equipment, especially whenopening and closing containers of this chemical. Sources ofignition, such as smoking and open flames, are prohibitedwhere this chemical is used, handled, or stored in a mannerthat could create a potential fire or explosion hazard.Wherever this chemical is used, handled, manufactured, orstored, use explosion-proof electrical equipment and fittings. A regulated, marked area should be established wherethis chemical is handled, used, or stored in compliance withOSHA Standard 1910.1045. |
| Shipping | This compound requires a shipping label of“POISONOUS/TOXIC MATERIALS, POISON GAS,CORROSIVE.” It falls in Hazard Class 6.1 and PackingGroup I. Procedures for the handling, use, and storage ofcylinders should be in compliance with OSHA 1910.101and 1910.169 with the recommendations of the CompressedGas Association. |
| Purification Methods | Fractionally distil the hydrazine through a 4-ft column packed with glass helices. Precipitate it as its oxalate from diethyl ether solution. After crystallising from 95% EtOH, the salt is decomposed with aqueous saturated NaOH, and the free base is distilled, dried over BaO and redistilled [McBride & Kruse J Am Chem Soc 79 572 1957]. Distillation and storage should be under nitrogen. [Beilstein 4 IV 3322.] |
| Incompatibilities | Forms explosive mixture with air; mayspontaneously ignite on contact with air and porous materials, such as asbestos, wood, earth, cloth, etc. Reacts withoxygen causing fire and explosion hazard. A strong reducing agent, this chemical is incompatible with strong acids,halogens, metallic mercury, copper alloys, brass, iron, ironsalts. Contact with strong oxidizers, such as nitric acid,nitrogen tetroxide, hydrogen peroxide, may cause spontaneous ignition. A strong base, this chemical is corrosive andreacts violently with acids. Attacks some plastics, rubber,and coatings. May accumulate static electrical charges, andmay cause ignition of its vapors |
1,1-Dimethylhydrazine Preparation Products And Raw materials
| Raw materials | Sodium hypochlorite-->Dimethylamine-->Sodium chlorate-->hypochlorous acid-->Benzophenone hydrazone |
| Preparation Products | FUSARIC ACID-->5-BUTYLPYRIDINE-2-CARBONITRILE-->1,2-Dimethylhydrazine Dihydrochloride-->Daminozide-->CHLORODIMETHYLAMINE-->1,1-Dimethyl-2-methylenehydrazine-->1-Amino-2-naphthol-->1-DIMETHYLAMINO-2-PROPYNE-->1,3-Oxazolidine |
