Introduction：Basic information about 1,2,3-propanetriyl tris(12-hydroxyoctadecanoate) CAS 139-44-6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
1,2,3-propanetriyl tris(12-hydroxyoctadecanoate) Basic information
| Product Name: | 1,2,3-propanetriyl tris(12-hydroxyoctadecanoate) |
| Synonyms: | 1,2,3-propanetriyl tris(12-hydroxyoctadecanoate);Glycerol 12-hydroxystearate;Octadecanoic acid, 12-hydroxy-, 1,2,3-propanetriyl ester;GLYCEROLTRIS(12-HYDROXYSTEARATE);TRIHYDROXYSTEARIN;trihydroxy;12-Hydroxystearic acid triglyceride;L-Glycerol tris(12-hydroxystearate) |
| CAS: | 139-44-6 |
| MF: | C57H110O9 |
| MW: | 939.48 |
| EINECS: | 205-364-6 |
| Product Categories: | |
| Mol File: | 139-44-6.mol |
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1,2,3-propanetriyl tris(12-hydroxyoctadecanoate) Chemical Properties
| Melting point | 89.4 °C |
| Boiling point | 872.4±30.0 °C(Predicted) |
| density | 0.964±0.06 g/cm3(Predicted) |
| pka | 15.10±0.20(Predicted) |
| Cosmetics Ingredients Functions | SKIN CONDITIONING
VISCOSITY CONTROLLING |
| InChIKey | WCOXQTXVACYMLM-UHFFFAOYSA-N |
| SMILES | C(OC(=O)CCCCCCCCCCC(O)CCCCCC)C(OC(=O)CCCCCCCCCCC(O)CCCCCC)COC(=O)CCCCCCCCCCC(O)CCCCCC |
| LogP | 18.484 (est) |
| EPA Substance Registry System | Glyceryl tris(12-hydroxystearate) (139-44-6) |
Safety Information
1,2,3-propanetriyl tris(12-hydroxyoctadecanoate) Usage And Synthesis
| Description | Glyceryl tris-12-hydroxystearate is a triester of glycerol and 12-hydroxystearic acid, ahydroxy fatty acid that is formed from the hydrogenation of the predominant castor oil fatty acid.Hydrogenation of castor oil results in a substance that is a waxy solid in nature which is alsoknown as castor wax. In addition to its use as a pesticide product inert ingredient, glyceryl tris12-hdyroxystearate is used as a component of speciality wax blends like crayons, lipsticks, andstick deodorants. |
| Uses | Glyceryl tris-12-hydroxystearate is used as a component of speciality wax blends likecrayons, lipsticks, and stick deodorants as well as being used in pharmaceuticals as an excipientin sustained release capsules. Other uses of glyceryl tris-12-hydroxystearate are as a thixotrophicagent in paints, coatings, inks, adhesives, and sealants. |
| Uses | Trihydroxystearin is used in cosmetic compositions. |
| Definition | Glyceryl tris- 12-hydroxystearate is a triester of glycerol and 12-hydroxystearic acid, ahydroxy fatty acid that is formed from the hydrogenation of the predominant castor oil fatty acid(O'Shea, 205). The chemical structure of glyceryl tris-12-hydroxystearate corresponds to hllyhydrogenated castor oil. Hydrogenation of castor oil results in a substance that is a waxy solid innature which is also known as castor wax. The hydrogenated form of castor oil has a wide arrayof uses including cosmetic and pharmaceutical applications. |
| Hazard | Glyceryl tris-12-hydroxystearate is a triglyceride that is similar to many other fats and oilsand is the fully hydrogenated form of the predominant castor oil fatty acid. Glyceryl tris-12-hydroxystearate is not expected to be absorbed via any route of exposure and is of low concernfor human health effects. Glyceryl tris-12-hydroxystearate is also readily degraded in theenvironment. Taking into consideration all available information on glyceryl tris- 12-hydroxystearate, ithas been determined that there is a reasonable certainty that no harm to any population subgroupwill result fi-om aggregate exposure to glyceryl tris- 12-hydroxystearate when considering dietaryexposure and all other non-occupational sources of pesticide exposure for which there is reliableinformation. Therefore, it is recommended that the exemptions from the requirement of atolerance established for residues of glyceryl tris-12-hydroxystearate idon raw agriculturalcommodities can be considered reassessed as safe under section 408(q) of the FFDCA. |
| Health Hazard | Glyceryl tris-12-hydroxystearate is a hydrogenated form of castor oil. There is no readilyavailable toxicity data on glyceryl tris-12-hydroxystearate. Limited data are available on castoroil; as part of the Joint FAOIWHO Expert Committee on Food Additives (JECFA) evaluation ofcastor oil as a food additive, it was noted that while low doses of castor oil are absorbed byhumans, higher does are not absorbed and laxation is observed, consistent with its long history ofuse as a laxative (JECFA, 1979). A structure activity relationship analysis of glyceryl tris-12-hydroxystearate was conducted by the Office of Pollution Prevention and Toxics (OPPT)Structure Activity Team. The OPPT assessment concluded that glyceryl tris-12-hydroxystearate was poorly absorbed via all routes of exposure and is of low concern for human health effects,with no identified health concerns (Appendix A). |
| Pharmacokinetics | Glyceryl tris-12-hydroxystearate is expected to be poorly absorbed by the gastrointestinal(GI) tract (OPPT, 2004). While no pharmacokinetic data are available on glyceryl tris-12-hydroxysterate, as an orally-administered laxative, castor oil is not absorbed in the GI tract and isexcreted unchanged in the feces. As part of its review of castor oil and derivatives as foodadditives, the European Commission's Scientific Committee for Food noted that small doses ofcastor oil are hydrolyzed and absorbed completely and can be stored and metabolized similar todietary fatty acids (SCF, 2003). |
1,2,3-propanetriyl tris(12-hydroxyoctadecanoate) Preparation Products And Raw materials
| Raw materials | TRIRICINOLEIN |
