1,3,5-Trihydroxy-4-prenylxanthone CAS 53377-61-0
Introduction：Basic information about 1,3,5-Trihydroxy-4-prenylxanthone CAS 53377-61-0, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
1,3,5-Trihydroxy-4-prenylxanthone Basic information
| Product Name: | 1,3,5-Trihydroxy-4-prenylxanthone |
| Synonyms: | 1,3,5-Trihydroxy-4-prenylxanthone;1,3,5-Trihydroxy-4-(3-Methylbut-2-en-1-yl)-9H-xanthen-9-one;9H-Xanthen-9-one, 1,3,5-trihydroxy-4-(3-methyl-2-buten-1-yl)-;1,3,5-Trihydroxy-4-(3-methyl-2-buten-1-yl)-9H-xanthen-9-one;5-Trihydroxy-4-prenylxanthone;1,3,5Trihydroxy4prenylxanthone,1,3,5 Trihydroxy 4 prenylxanthone |
| CAS: | 53377-61-0 |
| MF: | C18H16O5 |
| MW: | 312.32 |
| EINECS: | |
| Product Categories: | |
| Mol File: | 53377-61-0.mol |
1,3,5-Trihydroxy-4-prenylxanthone Chemical Properties
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| form | powder |
| color | Yellow |
Safety Information
| Description | 1,3,5-Trihydroxy-4-prenylxanthone is a relatively potent inhibitor of phosphodiesterase type 5 (PDE5), with an IC50 value of 3.0 μM. 1,3,5-Trihydroxy-4-prenylxanthone inhibits LPS-induced NF-κB and AP-1 activations by interfering with the posttranslational modification (phosphorylation and/or ubiquitinylation) of IRAK-1 in the cell membrane to impede TAK1-mediated activation of IKK and MAPKs signal transduction.3. 1,3,5-Trihydroxy-4-prenylxanthone shows in vitro inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with IC50 values of 56.3plusmn;0.4 and 46.0plusmn;0.3 M, respectively. |
| Uses | 1,3,5-Trihydroxy-4-prenylxanthone is a Na+/H+ exchange system (Na+/H+ Exchanger (NHE)) inhibitor with a minimum inhibitory concentration of 10 μg/mL[1]. 1,3,5-Trihydroxy-4-prenylxanthone is a phosphodiesterase type 5 (PDE5) (Phosphodiesterase (PDE)) inhibitor with an IC50 value of 3.0 μM[3]. 1,3,5-Trihydroxy-4-prenylxanthone inhibits Lipopolysaccharide (LPS) (Lipopolysaccharides (HY-D1056))-induced NO production in RAW264.7 macrophages, and has anti-inflammatory activities[2]. |
| target | NF-kB | IkB | AP-1 | JNK | ERK | TGF-β/Smad | AChR | IKK |
| IC 50 | PDE5: 3 μM (IC50); iNOS; Na+/H+ Exchanger |
| References | [1] [1] M Kobayashi, et al. Indonesian medicinal plants. XXI. Inhibitors of Na+/H+ exchanger from the bark of Erythrina variegata and the roots of Maclura cochinchinensis. Chem Pharm Bull (Tokyo). 1997 Oct;45(10):1615-9. DOI:10.1248/cpb.45.1615 [2] Wen-Fei Chiou, et al. 1,3,5-trihydroxy-4-prenylxanthone represses lipopolysaccharide-induced iNOS expression via impeding posttranslational modification of IRAK-1. Biochem Pharmacol. 2011 Mar 15;81(6):752-60. DOI:10.1016/j.bcp.2010.12.022 [3] Chalisa Sabphon, et al. Phosphodiesterase inhibitory activity of the flavonoids and xanthones from Anaxagorea luzonensis. Nat Prod Commun. 2015 Feb;10(2):301-3. PMID:25920267 |
1,3,5-Trihydroxy-4-prenylxanthone Preparation Products And Raw materials
