1,4-Butanediol CAS 110-63-4
Introduction：Basic information about 1,4-Butanediol CAS 110-63-4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
1,4-Butanediol Basic information
| Product Name: | 1,4-Butanediol |
| Synonyms: | 1,4-BUTYLENE GLYCOL;1,4-BUTANEDIOL;1,4-DIHYDROXYBUTANE;AKOS BBS-00004303;BDO;BUTANEDIOL, 1,4-;TETRAMETHYLENE GLYCOL;VERSALINK CURATIVE 1,4 BDO |
| CAS: | 110-63-4 |
| MF: | C4H10O2 |
| MW: | 90.12 |
| EINECS: | 203-786-5 |
| Product Categories: | Chemical;1,4 BDO;Building Blocks;Solvents;Solvent;solvents and intermediates;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds;Polyols;110-63-4;BDO |
| Mol File: | 110-63-4.mol |
1,4-Butanediol Chemical Properties
| Melting point | 16 °C (lit.) |
| Boiling point | 230 °C (lit.) |
| density | 1.017 g/mL at 25 °C (lit.) |
| vapor density | 3.1 (vs air) |
| vapor pressure | <0.1 hPa (20 °C) |
| refractive index | n |
| Fp | 135 °C |
| storage temp. | Store below +30°C. |
| form | Liquid |
| pka | 14.73±0.10(Predicted) |
| color | Clear colorless |
| Odor | Odorless |
| PH | 7-8 (500g/l, H2O, 20℃) |
| explosive limit | 1.95-18.3%(V) |
| Water Solubility | Miscible |
| Sensitive | Hygroscopic |
| BRN | 1633445 |
| Dielectric constant | 30.0（30℃） |
| Stability: | Stable. Combustible. Incompatible with strong oxidizing agents, mineral acids, acid chlorides, acid anhydrides. |
| Cosmetics Ingredients Functions | SOLVENT |
| Cosmetic Ingredient Review (CIR) | 1,4-Butanediol (110-63-4) |
| InChI | 1S/C4H10O2/c5-3-1-2-4-6/h5-6H,1-4H2 |
| InChIKey | WERYXYBDKMZEQL-UHFFFAOYSA-N |
| SMILES | OCCCCO |
| LogP | -0.88 at 25℃ |
| Surface tension | 45.33mN/m at 298.15K |
| CAS DataBase Reference | 110-63-4(CAS DataBase Reference) |
| NIST Chemistry Reference | 1,4-Butanediol(110-63-4) |
| EPA Substance Registry System | 1,4-Butanediol (110-63-4) |
Safety Information
| Hazard Codes | Xn |
| Risk Statements | 22-67 |
| Safety Statements | 36-23-24/25 |
| WGK Germany | 1 |
| RTECS | EK0525000 |
| Autoignition Temperature | 698 °F |
| TSCA | TSCA listed |
| HS Code | 29053980 |
| Storage Class | 10 - Combustible liquids |
| Hazard Classifications | Acute Tox. 4 Oral STOT SE 3 |
| Hazardous Substances Data | 110-63-4(Hazardous Substances Data) |
| Toxicity | LD50 orally in Rabbit: 1525 mg/kg LD50 dermal Rabbit > 2000 mg/kg |
| Chemical Properties | 1,4-butanediol (1,4-BD) is a colorless, viscous liquid derived from butane by placement of alcohol groups at each end of its molecular chain and is one of four stable isomers of butanediol.the hydroxyl function of each end group of the Butanediol reacts with different mono- and bifunctional reagents: for example with dicarboxylic acids to polyesters, with diisocyanates to polyurethanes, or with phosgene to polycarbonates. 1.4-Butanediol (BDO) is a high-quality intermediate. BDO and its derivatives are widely used for producing plastics, solvents, electronic chemicals and elastic fibers. Additionally BDO is also a building block for the synthesis of polyesterpolyols and polyetherpolyols. BASF is the most significant producer of 1,4-Butanediol and its derivatives worldwide. |
| Uses |
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| Uses | butylene glycol is a solvent with good antimicrobial action. It enhances the preservative activity of parabens. Butylene glycol also serves as a humectant and viscosity controller, and to mask odor. |
| Uses | 1,4-Butanediol is used to produce polybutyleneterephthalate, a thermoplastic polyester;and in making tetrahydrofuran, butyrolactones,and polymeric plasticizers. |
| Definition | ChEBI: Butane-1,4-diol is a butanediol that is butane in which one hydrogen of each of the methyl groups is substituted by a hydroxy group. A colourless, water-miscible, viscous liquid at room temperature (m.p. 16℃) with a high boiling point (230℃), it is mainly used for the production of other organic chemicals, particularly the solvent oxolane (also known as tetrahydrofuran or THF). It has a role as a neurotoxin, a protic solvent and a prodrug. It is a butanediol and a glycol. |
| Production Methods | Methods of manufacturing: The most prevalent 1,4-BD production route worldwide is BASF's Reppe process, which reacts acetylene and formaldehyde. Acetylene reacts with two equivalents of formaldehyde to form 1,4-butynediol, also known as but-2-yne- 1,4-diol. Hydrogenation of 1,4-butynediol gives 1,4-butanediol. 1,4-BD is also made on a large industrial scale by continuous hydrogenation of the 2-butyne- 1,4-diol over modified nickel catalysts. The one-stage flow process is carried out at 80 - 160°C and 300 bar. Mitsubishi uses a three-step process: (1) the catalytic reaction of butadiene and acetic acid yields 1,4-diacetoxy-2-butene; (2) subsequent hydrogenation gives 1,4-diacetoxybutane; and (3) hydrolysis leads to 1,4-butanediol. |
| Synthesis Reference(s) | The Journal of Organic Chemistry, 36, p. 2018, 1971 DOI: 10.1021/jo00813a043 Tetrahedron Letters, 33, p. 6371, 1992 DOI: 10.1016/S0040-4039(00)60976-0 |
| General Description | Odorless colorless liquid or solid (depending upon temperature). |
| Air & Water Reactions | Highly flammable. 1,4-Butanediol is hygroscopic. Water soluble. |
| Reactivity Profile | 1,4-Butanediol is heat and light sensitive. 1,4-Butanediol reacts with acid chlorides, acid anhydrides and chloroformates; reacts with oxidizing agents and reducing agents. 1,4-Butanediol is incompatible with isocyanates and acids; also incompatible with peroxides, perchloric acid, sulfuric acid, hypochlorous acid, nitric acid, caustics, acetaldehyde, nitrogen peroxide and chlorine. |
| Hazard | Toxic by ingestion. |
| Health Hazard | The acute toxic effects are mild. 1,4-Butanediolis less toxic than its unsaturate analogs,butenediol and the butynediol. The oralLD50 value in white rats and guinea pigsis ~2 mL/kg. The toxic symptoms fromingestion may include excitement, depressionof the central nervous system, nausea, anddrowsiness. |
| Health Hazard | Ingestion of large amounts needed to produce any symptoms. |
| Fire Hazard | Nonflammable liquid, flash point (open cup)121°C. |
| Safety Profile | A human poison by an unspecified route. Moderately toxic byingestion and intraperitoneal routes. Human systemic effects: altered sleep time. Combustible when exposed to heat or flame. To fight fire, use alcohol foam, mist, foam, CO2, dry chemical. Incompatible with oxidizing materials. When heated to decomposition it emits acrid smoke and fumes. |
| Solubility in water | 1,4-Butanediol is soluble in water, alcohols, esters, ketones, glycol ethers and glycol ether acetates(Butanediols, Butenediol, and Butynediol). |
| Purification Methods | Distil the glycol and store it over Linde type 4A molecular sieves, or crystallise it twice from anhydrous diethyl ether/acetone, and redistil it. It has been recrystallised from the melt and doubly distilled in vacuo in the presence of Na2SO4. [Beilstein 1 IV 2515.] |
| Toxics Screening Level | The Initial Risk Screening Level (ITSL) for 1,4-butanediol (CAS# 110-63-4) is 79 μg/m3 based on annual averaging time. |
1,4-Butanediol Preparation Products And Raw materials
| Raw materials | Formaldehyde-->Nickel-->1,3-Butadiene-->Acetylene-->2,3-Butanedione-->2-Butyne-1,4-diol-->2-chloro-1,3-butadiene-->cis-1,4-Dichloro-2-butene-->3-hydroxy-2-methyl propionaldehyde-->DIMETHYL MALEATE-->2-HYDROXYTETRAHYDROFURAN |
| Preparation Products | Tetrahydrofuran-->Gamma Butyrolactone-->Polyurethane-->Triethylene glycol dimethacrylate-->1,4-Dibromobutane-->Poly(butylene terephthalate)-->GD visible light curing composite resin-->PolyesterPolyol-->2,3-Dihydrofuran-->1,4-BUTANEDIOL DIACRYLATE-->4-Hydroxybutyl acrylate-->Polyvinylpyrrolidone-->Busulfan-->Pyrrolidine |
