Introduction：Basic information about 10-Nitrocamptothecin CAS 86639-62-5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
10-Nitrocamptothecin Basic information
| Product Name: | 10-Nitrocamptothecin |
| Synonyms: | RUBETICAN;CAMPTOTHECIN, 9-NITRO-20(S)-;9-NITRO-CPT;4α-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;9-Nitro-20(S)-camptothecine;(S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;(S)-4-Ethyl-4-hydroxy-9-nitro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;(S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinoline-3,14(4H,12H)-di |
| CAS: | 86639-62-5 |
| MF: | C20H15N3O6 |
| MW: | 393.35 |
| EINECS: | |
| Product Categories: | Natural Anti-cancer Medical Materials and It's Derivatives |
| Mol File: | 86639-62-5.mol |
|
10-Nitrocamptothecin Chemical Properties
| Boiling point | 827.4±65.0 °C(Predicted) |
| density | 1.63±0.1 g/cm3(Predicted) |
| pka | 11.17±0.20(Predicted) |
Safety Information
10-Nitrocamptothecin Usage And Synthesis
| Uses | Whether cells can divide depends on the two key points of entering S phase and M phase. Studies have found that 10-Nitrocamptothecin can induce apoptosis. After administration, both S phase and G2M phase of cell growth are delayed. Inhibition occurred throughout the cell cycle and was found to be dose- and time-dependent. |
| Definition | ChEBI: Rubitecan is a pyranoindolizinoquinoline that is camptothecin in which the hydrogen at position 9 has been replaced by a nitro group. It is a prodrug for 9-aminocamptothecin. It has a role as an antineoplastic agent, an EC 5.99.1.2 (DNA topoisomerase) inhibitor and a prodrug. It is a pyranoindolizinoquinoline, a C-nitro compound, a semisynthetic derivative, a tertiary alcohol and a delta-lactone. |
10-Nitrocamptothecin Preparation Products And Raw materials
