1-BENZYL-1,7-DIAZASPIRO[4,4]NONANE CAS 128244-01-9

Introduction：Basic information about 1-BENZYL-1,7-DIAZASPIRO[4,4]NONANE CAS 128244-01-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

1-BENZYL-1,7-DIAZASPIRO[4,4]NONANE Basic information

• Product Name: 1-BENZYL-1,7-DIAZASPIRO[4,4]NONANE
• Synonyms: 1-BENZYL-1,7-DIAZASPIRO[4,4]NONANE;1,7-Diazaspiro[4.4]nonane, 1-(phenylMethyl)-;1-Benzyl-1,7-diazaspiro[4.4]nonane heMioxalte;1-Benzyl-1,7-diazaspiro[4.4]nonane hemioxalate, 95%
• CAS: 128244-01-9
• MF: C14H20N2
• MW: 216.32
• Mol File: 128244-01-9.mol

1-BENZYL-1,7-DIAZASPIRO[4,4]NONANE Chemical Properties

• Boiling point: 328.1±17.0 °C(Predicted)
• density: 1.08±0.1 g/cm3(Predicted)
• storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• pka: 10.68±0.20(Predicted)

Safety Information

• Risk Statements: 36/37/38
• Safety Statements: 26-36
• HS Code: 29339900

1-BENZYL-1,7-DIAZASPIRO[4,4]NONANE Usage And Synthesis

Synthesis

The synthesis of the 1-benzyl-1,7-diazaspiro[4,4]nonane core structure (a spirocyclic diamine structure) typically involves a multi-step reaction to construct two fused pyrrolidine rings sharing a single spirocyclic carbon atom. A common approach is to utilize suitable linear or pre-cyclized precursors for reductive amination or cyclization. For example, the synthesis can begin with a protected diamine derivative followed by a key step, such as an intramolecular cyclization of a linear intermediate containing a primary amine and an electrophilic center (e.g., a toluenesulfonate or halide), to form one of the pyrrolidine rings. The second ring forms the spirocyclic center, typically constructed via a subsequent cyclization reaction or a [3+2] cycloaddition reaction. The final step is the introduction of a benzyl group, usually through N-alkylation of the secondary amine with benzyl bromide or benzyl chloride, or reductive amination with benzaldehyde, followed by removal of the remaining protecting group to yield 1-benzyl-1,7-diazaspiro[4.4]nonane.