Introduction：Basic information about 1-Bromo-2-nitrobenzene CAS 577-19-5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
1-Bromo-2-nitrobenzene Basic information
| Product Name: | 1-Bromo-2-nitrobenzene |
| Synonyms: | Benzene,1-bromo-2-nitro-;o-Nitrophenyl bromide;1-Bromo-2-nitrobenzene,98%;2-Bromonitrobenzene 98%;1-Bromo-2-nitrobenze;1-BROMO-2-NITROBENZENE FOR SYNTHESIS;1-BroMo-2-Nitrobenzene, Ultrapure;2- broMinenitrobenzene |
| CAS: | 577-19-5 |
| MF: | C6H4BrNO2 |
| MW: | 202.01 |
| EINECS: | 209-409-0 |
| Product Categories: | Aromatic Hydrocarbons (substituted) & Derivatives;Benzene derivates;Miscellaneous;Bromine Compounds;Nitro Compounds;Nitro Compounds;Nitrogen Compounds;Organic Building Blocks |
| Mol File: | 577-19-5.mol |
|
1-Bromo-2-nitrobenzene Chemical Properties
| Melting point | 40-42 °C (lit.) |
| Boiling point | 261 °C (lit.) |
| density | 1.7 g/cm3 (20℃) |
| refractive index | 1.6060 (estimate) |
| Fp | >230 °F |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | powder to crystal |
| color | Light yellow to Amber to Dark green |
| Water Solubility | insoluble |
| BRN | 2044109 |
| Stability: | Stable. Combustible. Incompatible with strong bases, strong oxidizing agents. |
| InChI | 1S/C6H4BrNO2/c7-5-3-1-2-4-6(5)8(9)10/h1-4H |
| InChIKey | ORPVVAKYSXQCJI-UHFFFAOYSA-N |
| SMILES | [O-][N+](=O)c1ccccc1Br |
| CAS DataBase Reference | 577-19-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzene, 1-bromo-2-nitro-(577-19-5) |
| EPA Substance Registry System | o-Bromonitrobenzene (577-19-5) |
Safety Information
| Hazard Codes | Xn,Xi |
| Risk Statements | 20/21/22-36/37/38-22 |
| Safety Statements | 36/37-36/37/39-26-22 |
| RIDADR | UN 3459 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | CY9040450 |
| Hazard Note | Irritant |
| TSCA | TSCA listed |
| HazardClass | 6.1 |
| PackingGroup | III |
| HS Code | 29049085 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
1-Bromo-2-nitrobenzene Usage And Synthesis
| Chemical Properties | white to light yellow crystal powder |
| Uses | 1-Bromo-2-nitrobenzene is used in organic synthesis. It also can react with 2-methylamino-benzoic acid to get N-methyl-N-(2-nitro-phenyl)-anthranilic acid. And it is also used in the preparation of 4-methoxy-2?-nitrodiphenyl ether, 1-methoxy-3,5-bis-(2-nitro-phenoxy)benzene. |
| Uses | 1-Bromo-2-nitrobenzene may be used in the preparation of:
- 4-methoxy-2′-nitrodiphenyl ether
- 1-methoxy-3,5-bis-(2-nitro-phenoxy)benzene
- 5-hydroxy-3-methoxy-2′-nitrodiphenyl ether
|
| General Description | 1-Bromo-2-nitrobenzene undergoes palladium[0]-mediated Ullmann cross-coupling reaction with a range of β-halo-enals, -enones or -esters to afford the corresponding β-aryl derivatives. Palladium[0]-mediated Ullmann cross-coupling reaction of 1-bromo-2-nitrobenzene with β-bromo-α,β-unsaturated aldehydes is reported. |
| Purification Methods | Crystallise it twice from pet ether, using charcoal before the first crystallisation. [Beilstein 5 III 618, 5 IV 728.] |
1-Bromo-2-nitrobenzene Preparation Products And Raw materials
| Raw materials | Cuprous bromide-->2-Nitroaniline |
| Preparation Products | 1-(2-NITROPHENYL)PIPERIDINE-->2-Aminodiphenylamine-->2-Bromo-6-nitrophenol-->5,11-dihydro-5-phenylindolo[3,2-b]carbazole-->10-Bromo-7-phenyl-7H-benzo[c]carbazole-->METHYL 2-NITROBENZOATE-->2-METHOXY-9H-CARBAZOLE-->2,2'-DINITRODIBENZYL-->3-BROMO-4-NITROANILINE-->5,7-Dihydro-7,7-dimethyl-indeno[2,1-b]carbazole-->2-Nitro-N-hydroxyethyl aniline-->3-Bromonitrobenzene-->2-Nitrodiphenylamine-->4-HYDROXY-2-METHYLQUINOLINE |
