1-Ethyl-2-pyrrolidone CAS 2687-91-4
Introduction：Basic information about 1-Ethyl-2-pyrrolidone CAS 2687-91-4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
1-Ethyl-2-pyrrolidone Basic information
| Product Name: | 1-Ethyl-2-pyrrolidone |
| Synonyms: | 1-ethyl-2-pyrrolidinon;1-ethyl-pyrrolidin-2-one;2-Pyrrolidinone, 1-ethyl-;Agsol Ex 2;ethyl-2-pyrrolidone;N-Ethyl-2-pyrrolidinone;N-Ethylpyrrolidinone;N-Ethylpyrrolidone |
| CAS: | 2687-91-4 |
| MF: | C6H11NO |
| MW: | 113.16 |
| EINECS: | 220-250-6 |
| Product Categories: | NEP;Building Blocks;Heterocyclic Building Blocks;Pyrrolidines;Pyrrolidones;2687-91-4 |
| Mol File: | 2687-91-4.mol |
1-Ethyl-2-pyrrolidone Chemical Properties
| Melting point | 87.5-88.5 °C |
| Boiling point | 97 °C/20 mmHg (lit.) |
| density | 0.992 g/mL at 25 °C (lit.) |
| vapor pressure | 18Pa at 20℃ |
| refractive index | n |
| Fp | 169 °F |
| storage temp. | Sealed in dry,Room Temperature |
| pka | -0.41±0.20(Predicted) |
| form | Liquid |
| color | Clear |
| PH | 8-9 (100g/l, H2O, 20℃) |
| biological source | rabbit |
| explosive limit | 1.3-7.7%(V) |
| Water Solubility | 1000g/L at 23℃ |
| Specific Activity | 4.25-5.75nmol/min·mg |
| BRN | 107971 |
| Cosmetics Ingredients Functions | SOLVENT |
| InChI | 1S/C6H11NO/c1-2-7-5-3-4-6(7)8/h2-5H2,1H3 |
| InChIKey | ZFPGARUNNKGOBB-UHFFFAOYSA-N |
| SMILES | CCN1CCCC1=O |
| LogP | -0.2 at 20℃ |
| Surface tension | 36.5mN/m at 293.15K |
| CAS DataBase Reference | 2687-91-4(CAS DataBase Reference) |
| NIST Chemistry Reference | 1-Ethyl-2-pyrrolidinone(2687-91-4) |
| EPA Substance Registry System | 2-Pyrrolidinone, 1-ethyl- (2687-91-4) |
Safety Information
| Hazard Codes | Xn,T |
| Risk Statements | 22-36-62-41-61 |
| Safety Statements | 26-36-45-36/37/39-53 |
| RIDADR | UN1993 |
| WGK Germany | 1 |
| RTECS | UY5769250 |
| Autoignition Temperature | 245°C (DIN 51794) |
| TSCA | TSCA listed |
| HazardClass | 3 |
| HS Code | 29337900 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Eye Dam. 1 Repr. 1B |
| Chemical Properties | N-Ethyl-2-pyrrolidone (NEP) is a colorless, clear liquid that serves as a low-volatility aprotic solvent classified as a reproductive toxicant. It is characterized by high solvency, low vapor pressure, and a low dielectric constant. |
| Uses | 1-Ethyl-2-pyrrolidone was used to modify coir fiber (from Cocos nucifera) by photocuring. |
| Application | N-Ethyl-2-pyrrolidone is commonly used as a solvent. It has a low boiling point, which makes it suitable for use in low light and at constant pressure. It is also used as an intermediate in the preparation of polycarboxylic acid. It has been shown to be involved in both viscosity and hydrogen bonding. |
| Definition | ChEBI: 1-Ethyl-2-pyrrolidinone is a N-alkylpyrrolidine. |
| General Description | 1-Ethyl-2-pyrrolidone is a transdermal absorption-enhancing compound and mechanism of its effect on multilammellar liposome of stratum corneum lipid has been studied. |
| Flammability and Explosibility | Non flammable |
| Biological Activity | CDK7 gene is a member of the cyclin-dependent protein kinase family th at is important regulators of cell cycle progression. CDK7 forms a trimeric complex with cyclin H and MAT1, which functions as a CDK-activating kinase (CAK). CDK7 is an essential component of the transcription factor TFIIH th at is involved in transcription initiation and DNA repair. CDK7 is thought to serve as a direct link between the regulation of transcription and the cell cycle. |
| Side effects | Neurotoxins - Acute Solvent Syndrome Occupational Hepatotoxin - Secondary Hepatotoxin: Cases of possible toxic effects in an occupational setting depending on human ingestion or experimental poisoning of animals. Reproductive toxin - A chemical that is toxic to the reproductive system, including offspring defects and damage to male or female reproductive function. Reproductive toxicity includes developmental effects. |
| Safety Profile | Moderately toxic by ingestion. An eye irritant. Combustible. When heated to decomposition it emits toxic fumes of NOx. |
| Toxics Screening Level | The initial threshold screening level (ITSL) for 1-ethyl-2-pyrrolidone (CAS # 2687-91-4) is 4.9 μg/m3 based on an annual averaging time. |
1-Ethyl-2-pyrrolidone Preparation Products And Raw materials
| Raw materials | TRIMETHYLSILYLBENZENESULFONATE-->Ethyl benzenesulphonate-->1-TRIMETHYLSILYL-2-PYRROLIDINONE |
