1-ETHYL-6-FLUORO-7-(4-METHYLPIPERAZIN-1-YL)-4-OXO-QUINOLINE-3-CARBOXYLIC ACID CAS 149676-40-4

Introduction：Basic information about 1-ETHYL-6-FLUORO-7-(4-METHYLPIPERAZIN-1-YL)-4-OXO-QUINOLINE-3-CARBOXYLIC ACID CAS 149676-40-4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

1-ETHYL-6-FLUORO-7-(4-METHYLPIPERAZIN-1-YL)-4-OXO-QUINOLINE-3-CARBOXYLIC ACID Basic information

• Product Name: 1-ETHYL-6-FLUORO-7-(4-METHYLPIPERAZIN-1-YL)-4-OXO-QUINOLINE-3-CARBOXYLIC ACID
• Synonyms: RB-1589;PERFLOXACINE;PEFLOXACINE MESYLATE DIHYDRATE;PEFLOXACINE METHANSULFONATE DIHYDRATE;PEFLOXACIN MESYLATE DIHYDRATE;PEFLOXACIN METHANESULFONATE;PEFLOXACIN METHANE SULFONATE DIHYDRATE;EU-5306
• CAS: 149676-40-4
• MF: C18H28FN3O8S
• MW: 465.49
• EINECS: 629-149-5
• Product Categories: MYCOSPOR
• Mol File: 149676-40-4.mol

1-ETHYL-6-FLUORO-7-(4-METHYLPIPERAZIN-1-YL)-4-OXO-QUINOLINE-3-CARBOXYLIC ACID Chemical Properties

• Melting point: 271°C
• Boiling point: 529℃
• Fp: >110°(230°F)
• storage temp.: Inert atmosphere,2-8°C
• solubility: H2O: soluble50mg/mL
• form: powder
• Water Solubility: Freely soluble in water
• Sensitive: Light Sensitive
• InChI: 1S/C17H20FN3O3.CH4O3S.2H2O/c1-3-20-10-12(17(23)24)16(22)11-8-13(18)15(9-14(11)20)21-6-4-19(2)5-7-21;1-5(2,3)4;;/h8-10H,3-7H2,1-2H3,(H,23,24);1H3,(H,2,3,4);2*1H2
• InChIKey: LEULAXMUNMRLPW-UHFFFAOYSA-N
• SMILES: O.O.CS(O)(=O)=O.CCN1C=C(C(O)=O)C(=O)c2cc(F)c(cc12)N3CCN(C)CC3
• CAS DataBase Reference: 149676-40-4(CAS DataBase Reference)

Safety Information

• Hazard Codes: Xn
• Risk Statements: 22-36
• Safety Statements: 26
• WGK Germany: 3
• RTECS: VB2002200
• HS Code: 29335990
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Eye Irrit. 2

1-ETHYL-6-FLUORO-7-(4-METHYLPIPERAZIN-1-YL)-4-OXO-QUINOLINE-3-CARBOXYLIC ACID Usage And Synthesis

Chemical Properties

White powder

Uses

antifungal, calmodulin antagonist

Uses

Pefloxacin Mesylate Dihydrate is an analog of norfloxacin that inhibits topoisomerase.

Biological Activity

Pefloxacin inhibits the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase is thought to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV is thought to be the primary target in gram-positive organisms. The inhibition of the topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. Therefore, DNA replication and transcription is inhibited . Pefloxacin is an analog of norfloxacin.

IC 50

Quinolone