1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde CAS 137076-22-3
Introduction：Basic information about 1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde CAS 137076-22-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde Basic information
| Product Name: | 1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde |
| Synonyms: | 1-(tert-butoxycarbonyl)-4-formylpiperidine;1-BOC-4-FORMYLPIPERIDINE 95%;1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde;Piperidine-4-carboxaldehyde, N-BOC protected;TERT-BUTYL 4-FORMYLPIPERIDINE-1-CARBOXYLATE;1-Piperidinecarboxylic acid, 4-formyl-, 1,1-dimethylethyl ester;1-TERT-BUTOXYCARBONYLPIPERIDINE-4-CARBOXALDEHYDE;tert-Butyl 4-formyl-1-piperidinecarboxylate |
| CAS: | 137076-22-3 |
| MF: | C11H19NO3 |
| MW: | 213.27 |
| EINECS: | 203-107-6 |
| Product Categories: | C11;Chemical Synthesis;Piperidine;Heterocyclic Building Blocks;Organic Building Blocks;Piperidines;Carbonyl Compounds;Heterocycles;pharmacetical;Aldehydes;Pyrans, Piperidines & Piperazines;Inhibitors;Building Blocks;C10-C12 |
| Mol File: | 137076-22-3.mol |
1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde Chemical Properties
| Melting point | 34-40℃ |
| Boiling point | 295.4±33.0 °C(Predicted) |
| density | 1.114±0.06 g/cm3(Predicted) |
| Fp | >110℃ |
| storage temp. | 2-8°C |
| solubility | Soluble in methanol. |
| form | Oil |
| pka | -2.13±0.40(Predicted) |
| color | Clear Yellow |
| Sensitive | Air Sensitive |
| InChI | InChI=1S/C11H19NO3/c1-11(2,3)15-10(14)12-6-4-9(8-13)5-7-12/h8-9H,4-7H2,1-3H3 |
| InChIKey | JYUQEWCJWDGCRX-UHFFFAOYSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CCC(C=O)CC1 |
| CAS DataBase Reference | 137076-22-3(CAS DataBase Reference) |
Safety Information
| Hazard Codes | Xi,N,Xn |
| Risk Statements | 36/37/38-50-22 |
| Safety Statements | 26-36/37/39-61 |
| RIDADR | UN 3077 9/PG 3 |
| WGK Germany | WGK 3 |
| HS Code | 29333990 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral Aquatic Acute 1 Aquatic Chronic 1 Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
| Chemical Properties | Clear Yellow Oil |
| Uses | Reactant for synthesis of:• ;Pim-1 inhibitors1• ;Selective GPR119 agonists for type II diabetes2• ;M-tropic (R5) HIV-1 replication inhibitors3• ;HDAC inhibitors4• ;Selective 5-HT6 antagonists5Reactant for three-component vinylogous Mannich reactions6 |
| Uses | 1-Boc-piperidine-4-carboxaldehyde is used as reactant for synthesis of Pim-1 inhibitors, selective GPR119 agonists for type II diabetes, M-tropic (R5) HIV-1 replication inhibitors, HDAC inhibitors and selective 5-HT6 antagonists. It is also used as reactant for three-component vinylogous Mannich reactions |
| Uses | An intermediate for polycyclic indazole derivatives that are ERK inhibitors. |
1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde Preparation Products And Raw materials
| Raw materials | Dichloromethane-->Lithium Aluminum Hydride-->Di-tert-butyl dicarbonate-->Sodium acetate-->Manganese dioxide-->Pyridinium chlorochromate-->Isonipecotic acid-->4-Piperidinemethanol |
| Preparation Products | tert-butyl 2-oxo-8-azaspiro[4.5]decane-8-carboxylate-->tert-butyl 4-(1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate-->1-BOC-PIPERIDIN-4-YLPROPIONIC ACID-->TERT-BUTYL 9-OXO-3-AZASPIRO[5.5]UNDECANE-3-CARBOXYLATE-->1-Boc-4-(2-aMino-1-hydroxybutyl)piperidine-->tert-butyl 4-(2-fluoro-3-hydroxypropyl)piperidine-1-carboxylate-->1-Boc-4-(1-phenylacetoxyallyl)piperidine-->CHEMBRDG-BB 4005904 |
