2,2,6,6-Tetramethyl-4-piperidone hydrochloride CAS 33973-59-0

Introduction：Basic information about 2,2,6,6-Tetramethyl-4-piperidone hydrochloride CAS 33973-59-0, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

2,2,6,6-Tetramethyl-4-piperidone hydrochloride Basic information

• Product Name: 2,2,6,6-Tetramethyl-4-piperidone hydrochloride
• Synonyms: 4-Piperidinone, 2,2,6,6-tetramethyl-, hydrochloride;2,2,6,6-Tetramethyl-4-piperidinone·hydrochloride;2,2,6,6-Tetramethyl-4-piperidone hydrochloride,97%;4-Oxo-2,2,6,6-tetramethylpiperidine hydrochloride;2,2,6,6-Tetramethyl-4-azacyclohexanone HydrochlorideTriacetonamine Hydrochloride;2,2,6,6-Tetramethylpiperidin-4-onehydrochloride97%;2,2,6,6-TETRAMETHYL-4-PIPERIDONE HYDROCHLORIDE;2,2,6,6-TETRAMETHYLPIPERIDONE-4 HYDROCHLORIDE
• CAS: 33973-59-0
• MF: C9H18ClNO
• MW: 191.7
• EINECS: 251-769-6
• Product Categories: Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks;Heterocyclic Building Blocks;Piperidones;Building Blocks
• Mol File: 33973-59-0.mol

2,2,6,6-Tetramethyl-4-piperidone hydrochloride Chemical Properties

• Melting point: 198 °C (dec.)(lit.)
• storage temp.: Sealed in dry,Room Temperature
• form: powder
• color: White to off-white
• BRN: 4154554
• InChI: 1S/C9H17NO.ClH/c1-8(2)5-7(11)6-9(3,4)10-8;/h10H,5-6H2,1-4H3;1H
• InChIKey: ZXNWYMNKYXUZGM-UHFFFAOYSA-N
• SMILES: Cl[H].CC1(C)CC(=O)CC(C)(C)N1
• LogP: 1.323 (est)
• CAS DataBase Reference: 33973-59-0(CAS DataBase Reference)
• EPA Substance Registry System: 4-Piperidinone, 2,2,6,6-tetramethyl-, hydrochloride (33973-59-0)

Safety Information

• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36-24/25
• WGK Germany: 3
• F: 8
• Hazard Note: Irritant
• TSCA: TSCA listed
• HS Code: 2933399990
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

2,2,6,6-Tetramethyl-4-piperidone hydrochloride Usage And Synthesis

Chemical Properties

white to slightly beige crystalline powder

Uses

2,2,6,6-Tetramethyl-4-piperidone hydrochloride has been used as a reagent injected in the micromixer using a Rheodyne injection valve for introducing discrete sample pulses into the miniaturised-SYNthesis and Total Analysis System (πSYNTAS).

in vivo

Triacetonamine (Purchased from MCE; 200 mg, 300 mg, 400 mg/Kg/day; gavage; 2 days) hydrochloride shows typical hepatoenteropathology of ALF with 300 mg/Kg/day and 400 mg/Kg/day, while the group of 400 mg/Kg/day had higher mortality^[2].

• Animal Model: Rats (half male and female, 6-8 weeks old, 200?±?10 g)^[2]
• Dosage: 200 mg, 300 mg, 400 mg/Kg
• Administration: Gavage; daily; 2 days
• Result: Showed typical hepatoenteropathology of ALF with 300 mg/Kg/day and 400 mg/Kg/day, while the group of 400 mg/Kg/day had higher mortality.

Purification Methods

Purify the salt by recrystallisation from EtOH/Et2O, MeCN or Me2CO/MeOH. The free base has m 37-39o (after sublimation), b 102-105o/18mm, and the hydrate has m 56-58o (wet Et2O); the hydrobromide has m 203o (from EtOH/Et2O), and the picrate has m 196o (from aqueous EtOH). [Sandris & Ourisson Bull Soc Chim Fr 345 1958, Beilstein 21 H 246, 21 I 273, 21 II 222, 21 III/IV 3278, 21/6 V 538.]