2,4-DICHLORO-3-FLUORONITROBENZENE CAS 393-79-3
2,4-DICHLORO-3-FLUORONITROBENZENE Basic information
| Product Name: | 2,4-DICHLORO-3-FLUORONITROBENZENE |
| Synonyms: | 1,3-dichloro-2-fluoro-4-nitrobenzene;2,4-DICHLORO-3-FLUORONITROBENZENE;2,4-Dichloro-3-Fluoro-1-nitrobenzene;2,4-Dichloro-3-fluroronitrobenzene;1,3-dichloro-2-fluoro-4-nitro-benzene;Benzene, 1,3-dichloro-2-fluoro-4-nitro- |
| CAS: | 393-79-3 |
| MF: | C6H2Cl2FNO2 |
| MW: | 209.99 |
| EINECS: | |
| Product Categories: | 1 |
| Mol File: | 393-79-3.mol |
2,4-DICHLORO-3-FLUORONITROBENZENE Chemical Properties
| Boiling point | 280°C |
| density | 1.622±0.06 g/cm3(Predicted) |
| storage temp. | Store at room temperature |
| form | liquid |
| color | Clear |
| CAS DataBase Reference | 393-79-3(CAS DataBase Reference) |
Safety Information
| Hazard Codes | Xi |
| Hazard Note | Irritant |
| HS Code | 2904990090 |
| Synthesis | 2268-05-5 393-79-3 General procedure for the synthesis of 2,4-dichloro-3-fluoronitrobenzene from 2,6-dichlorofluorobenzene: 2,6-dichlorofluorobenzene was dissolved in 20% dichloromethane solution, and nitric acid was introduced through a flat streamer at a flow rate of 11.9 mL/min, which corresponds to a flow rate of nitric acid of 0.27 mL/min. At the same time, sulfuric acid was introduced through a flat streamer at a flow rate of 25.2 mL/min. sulfuric acid, corresponding to a flow rate of sulfuric acid of 0.46 mol/min. sulfuric acid and nitric acid complete mixing in the microchannel reactor 1. Next, 2,6-dichlorofluorobenzene was introduced in dichloromethane via a flat streamer at a flow rate of 38.5 mL/min, which corresponds to a flow rate of 0.27 mol/min of 2,6-dichlorofluorobenzene in microchannel reactor 2. At this point, the reaction of 2,6-dichlorofluorobenzene with the mixed acid was initiated, wherein the molar ratio of 2,6-dichlorofluorobenzene to nitric acid was 1:1. The temperature of the reaction was 40° C. The reaction residence time in each of the microchannel reactors was 0.5 mL/min. The reaction residence time in the microchannel reactor was 33 s and the system pressure was maintained at 0.7 MPa. After the reaction was completed, the product was collected from the outlet. After post-treatment, the conversion of 2,6-dichlorofluorobenzene was 100% and the selectivity of 2,4-dichloro-3-fluoronitrobenzene was 94%. The product was washed and dried in a step to give a pure product. |
| References | [1] Patent: CN104478731, 2016, B. Location in patent: Paragraph 0084-0086 [2] Recueil des Travaux Chimiques des Pays-Bas, 1956, vol. 75, p. 186 [3] Journal of the American Chemical Society, 1959, vol. 81, p. 94,95, 97 |
2,4-DICHLORO-3-FLUORONITROBENZENE Preparation Products And Raw materials
| Raw materials | 1,3-Dichloro-2-fluorobenzene-->Sulfuric acid-->Dichloromethane-->Nitric acid |
| Preparation Products | 3-CHLORO-2-FLUOROANISOLE |
