2,4-Difluoronitrobenzene CAS 446-35-5
Introduction：Basic information about 2,4-Difluoronitrobenzene CAS 446-35-5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
2,4-Difluoronitrobenzene Basic informationSynthesis
| Product Name: | 2,4-Difluoronitrobenzene |
| Synonyms: | 1,3-difluoro-4-nitrobenzene;1-Nitro-2,4-difluorobenzene;2,4-difluoro-1-nitro-benzen;2,4-Difluronitrobenzene;Benzene, 2,4-difluoro-1-nitro-;2,4-DIFLUORO-1-NITROBENZENE;2,4-DIFLUORONITROBENZENE;2,4-DIFLUORO NITROBENZEN |
| CAS: | 446-35-5 |
| MF: | C6H3F2NO2 |
| MW: | 159.09 |
| EINECS: | 207-167-0 |
| Product Categories: | Fluorine series;alkyl Fluorine| nitro-compound;HALIDE;Aromatic Hydrocarbons (substituted) & Derivatives |
| Mol File: | 446-35-5.mol |
2,4-Difluoronitrobenzene Chemical Properties
| Melting point | 9-10 °C (lit.) |
| Boiling point | 203-204 °C (lit.) |
| density | 1.451 g/mL at 25 °C (lit.) |
| vapor density | >1 (vs air) |
| refractive index | n |
| Fp | 195 °F |
| storage temp. | Sealed in dry,Room Temperature |
| form | clear liquid |
| color | Light yellow to Brown |
| Specific Gravity | 1.45 |
| Water Solubility | Insoluble in water. |
| BRN | 2048034 |
| Stability: | Stable. Incompatible with strong bases, strong oxidizing agents. Combustible. |
| InChI | 1S/C6H3F2NO2/c7-4-1-2-6(9(10)11)5(8)3-4/h1-3H |
| InChIKey | RJXOVESYJFXCGI-UHFFFAOYSA-N |
| SMILES | [O-][N+](=O)c1ccc(F)cc1F |
| CAS DataBase Reference | 446-35-5(CAS DataBase Reference) |
| NIST Chemistry Reference | 2,4-Difluoronitrobenzene(446-35-5) |
| EPA Substance Registry System | 2,4-Difluoronitrobenzene (446-35-5) |
Safety Information
| Hazard Codes | T,Xi,Xn |
| Risk Statements | 25-36/37/38-23/24/25-20/21/22 |
| Safety Statements | 26-45-36/37/39-23 |
| RIDADR | UN 2810 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS | CZ5730000 |
| Hazard Note | Irritant |
| TSCA | TSCA listed |
| HazardClass | 6.1 |
| PackingGroup | III |
| HS Code | 29049090 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 3 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
| Synthesis | KF with n-Hexadecyltrimethylammonium bromide as the PTC has been shown recently to work in dimethylformamide (DMF), important owing to the low cost16 of DMF. |
| Chemical Properties | yellow liquid |
| Uses | 2,4-Difluoronitrobenzene has been used in the synthesis of: 2,4-difluoro-5-nitrobenzenesulfonic acid via sulfonation reaction; (±)-horsfiline; resin-bound 2-arylaminobenzimidazoles. 2,?4-?Difluoronitrobenzene is a reactant in the preparation of 4-?thiazolidinone derivatives as antimicrobial agents. |
| Uses | 2,4-Difluoronitrobenzene has been used in the synthesis of 2,4-difluoro-5-nitrobenzenesulfonic acid via sulfonation reaction, (±)-horsfiline and resin-bound-2-arylaminobenzimidazoles. |
| Uses | 2,4-Difluoronitrobenzene has been used in the synthesis of:
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| General Description | Nucleophilic aromatic substitution of 2,4-difluoronitrobenzene with morpholine has been investigated using flow reactor with simulated moving bed (SMB) chromatography module. |
| References | [1] Catalysis Today, 2012, vol. 198, # 1, p. 300 - 304 [2] Patent: US2009/99387, 2009, A1. Location in patent: Page/Page column 8 [3] Patent: US2009/99387, 2009, A1. Location in patent: Page/Page column 7-9 [4] Tetrahedron, 1995, vol. 51, # 22, p. 6363 - 6376 [5] Journal of the American Chemical Society, 1956, vol. 78, p. 6034,6037 |
2,4-Difluoronitrobenzene Preparation Products And Raw materials
| Raw materials | 1,3-Difluorobenzene-->tetrakis(N,N-DIethylaMino)phosphorus broMide-->Tetrabutylphosphonium bromide-->Potassium fluoride-->TRIHEXYL(TETRADECYL)PHOSPHONIUM TETRAFLUOROBORATE-->Dimethyl sulfoxide-->2,4-Dichloronitrobenzene |
| Preparation Products | 2,4-Difluoroaniline-->5-Fluoro-2-oxindole-->3-Fluoro-4-nitroanisole-->3-Fluoro-4-nitroaniline-->1,5-Difluoro-2,4-dinitrobenzene-->2,6-Difluoronitrobenzene-->2-Chloro-4-fluoronitrobenzene-->1-Fluoro-3-nitrobenzene |
