2,4-Dimethylphenylhydrazine hydrochloride CAS 60480-83-3
2,4-Dimethylphenylhydrazine hydrochloride Basic information
| Product Name: | 2,4-Dimethylphenylhydrazine hydrochloride |
| Synonyms: | 2,4-DIMETHYLPHENYLHYDRAZINE HCL;2,4-DIMETHYLPHENYLHYDRAZINE HYDROCHLORIDE;1-(2,4-DIMETHYLPHENYL)HYDRAZINE HYDROCHLORIDE;1-(2,4-Dimethylphenyl)hydrazineHCl;2,4-Dimethylphenylhydrazine hydrochloride 98%;4-hydrazinyl-N,N-diMethylaniline;4-Hydrazino-m-xylene hydrochloride;2,4-Dimethylphenylhydrazine HCI |
| CAS: | 60480-83-3 |
| MF: | C8H13ClN2 |
| MW: | 172.66 |
| EINECS: | |
| Product Categories: | Hydrazines;Nitrogen Compounds;Organic Building Blocks;Building Blocks;Chemical Synthesis;Nitrogen Compounds;Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes;Phenylhydrazine;API intermediates;Organic Building Blocks |
| Mol File: | 60480-83-3.mol |
2,4-Dimethylphenylhydrazine hydrochloride Chemical Properties
| Melting point | 180 °C |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | solid |
| color | Light beige/brown |
| Sensitive | Hygroscopic |
| CAS DataBase Reference | 60480-83-3(CAS DataBase Reference) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 26-36-36/37 |
| WGK Germany | 3 |
| Hazard Note | Harmful/Irritant |
| HS Code | 2928009090 |
| Chemical Properties | white to light yellow crystal powde |
| Synthesis | 95-68-1 60480-83-3 Example 13, Preparation of 2,4-dimethylphenylhydrazine hydrochloride (Compound 13): to a mixed solution of 2,4-dimethylaniline (35.4 mL; 36.3 g; 0.3 mol) cooled to 0 °C and concentrated hydrochloric acid (220 mL), aqueous sodium nitrite (20.6 g; 0.3 mol dissolved in 60 mL of water) was slowly added dropwise with a controlled rate of acceleration of dropwise addition to maintain the temperature of the reaction at a temperature not The rate of acceleration was controlled to maintain the reaction temperature not exceeding 5 °C. Upon completion of the reaction, the resulting solution was filtered and added to a solution of stannous chloride (124 g; 0.65 mol) in concentrated hydrochloric acid (124 mL) that had been pre-cooled to 5 °C with vigorous stirring. Subsequently, the resulting precipitate was separated by filtration, suspended in water (500 mL) and adjusted to pH 12 with sodium hydroxide solution (40%).The reaction mixture was extracted with ether (3 x 200 mL), the ether layers were combined and dried over anhydrous magnesium sulfate. The dried ether solution was passed through dry HCl gas until the precipitation was complete. The precipitate was collected by filtration, washed with ether and dried in a vacuum desiccator using phosphorus pentoxide as desiccant to give 2,4-dimethylphenylhydrazine hydrochloride (compound 13) in 18.5 g (35.8% yield). UV maximum absorption wavelength λmax 281 nm. mass spectrum (MALDI) (C8H12N2): measured value m/z 137.2, calculated value m/z 136.19. 1H-NMR (D2O), δ (ppm): 2.03 (3H, s, para-CH3), 2.08 (3H, s, o- CH3), 6.72 (1H, s, aryl ring H ), 6.93 (2H, d, aryl ring H). |
| References | [1] Patent: EP2157088, 2010, A1. Location in patent: Page/Page column 43-44 [2] Journal of Organic Chemistry, 2011, vol. 76, # 13, p. 5295 - 5308 [3] Bioorganic and Medicinal Chemistry Letters, 2018, vol. 28, # 3, p. 529 - 532 [4] European Journal of Medicinal Chemistry, 2018, vol. 156, p. 137 - 147 |
2,4-Dimethylphenylhydrazine hydrochloride Preparation Products And Raw materials
| Raw materials | 2,4-Dimethyl aniline-->Sodium nitrite-->Stannous chloride-->Hydrochloric acid |
| Preparation Products | (2,4-dimethylphenyl)hydrazine |
