Introduction：Basic information about 2,5-Dichlorobenzophenone CAS 16611-67-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
2,5-Dichlorobenzophenone Basic information
| Product Name: | 2,5-Dichlorobenzophenone |
| Synonyms: | 2,5-DICHLOROBENZOPHENONE;2,5-Dichlorobenzophenone 98%;(2,5-Dichlorophenyl)-(phenyl)methanone;2,5-Dichlorophenylphenyl ketone;2,5-Dichlorobenzophe;Methanone, (2,5-dichlorophenyl)phenyl- |
| CAS: | 16611-67-9 |
| MF: | C13H8Cl2O |
| MW: | 251.11 |
| EINECS: | 605-427-1 |
| Product Categories: | Aromatic Benzophenones & Derivatives (substituted) |
| Mol File: | 16611-67-9.mol |
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2,5-Dichlorobenzophenone Chemical Properties
| Melting point | 87-88°C |
| Boiling point | 240-260 °C |
| density | 1.311±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| form | crystals |
| color | Off-white to brown |
| InChI | InChI=1S/C13H8Cl2O/c14-10-6-7-12(15)11(8-10)13(16)9-4-2-1-3-5-9/h1-8H |
| InChIKey | FAVKIHMGRWRACA-UHFFFAOYSA-N |
| SMILES | C(C1=CC(Cl)=CC=C1Cl)(C1=CC=CC=C1)=O |
| CAS DataBase Reference | 16611-67-9(CAS DataBase Reference) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36/37/39 |
| Hazard Note | Harmful |
| TSCA | TSCA listed |
| HazardClass | IRRITANT |
| HS Code | 2914790090 |
2,5-Dichlorobenzophenone Usage And Synthesis
| Uses | 2,5-Dichlorobenzophenones can be used as starting materials for general, pharmaceutical and polymer synthesis. For example, using such compounds to prepare substituted para-polyphenylenes should proceed readily by metal-catalyzed aryl coupling of the 2,5-dichlorophenyl group of these compounds. Polyphenylenes formed from these compounds will have pendant side groups comprising the carbonyl, and the aryl or pyridyl group bonded thereto. |
| Synthesis | To a 22 L, three-necked flask fitted with a thermometer, mechanical stirrer and a Vigreux column connected to an aqueous NaOH scrubbing tower, was added 1,4-dichlorobenzene (3 Kg, 26.4 mol) and benzoyl chloride (2.6 Kg, 18.55 mol). The mixture was heated to 80° C. to give a homogeneous solution. Aluminum chloride (5.5 Kg, 41.25 mol) was added over 12 min. with stirring. (The molar ratio of reactants was 2.2:1.4:1.0 (AlCl3 : Dichlorobenzene: Benzoyl Chloride)). The resulting mixture was heated to 140° C. over 60 min, followed by heating to 175° C. over 30 min. The heating was stopped at 175° C. The mixture was allowed to cool to 80° C. over two hours and poured into a well-stirred mixture of ice and water (ca. 25 L water and 15 Kg of ice) over 30 min. The organic solid was collected by filtration and dissolved in 7 L of toluene. The solution was washed with aqueous sodium bicarbonate and dried. Toluene was removed by distillation. Pure 2,5-dichlorobenzophenone was isolated in 80% yield after recrystallization from hexane and toluene. |
| References | [1] Patent: US5210313, 1993, A
[2] Patent: US5210313, 1993, A
[3] Recueil des Travaux Chimiques des Pays-Bas, 1931, vol. 50, p. 753,779
[4] Journal fuer Praktische Chemie (Leipzig), 1933, vol. <2> 138, p. 311 |
2,5-Dichlorobenzophenone Preparation Products And Raw materials
| Raw materials | 4-chloro-2-(dichloro-phenyl-methyl)-1-diphenoxyphosphoryloxy-benzene-->1,4-Dichlorobenzene-->Benzoyl chloride-->Toluene-->Sodium hydroxide-->Water |
| Preparation Products | Lorazepam |
