Introduction：Basic information about 2',5'-Dimethoxyacetophenone CAS 1201-38-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
2',5'-Dimethoxyacetophenone Basic information
| Product Name: | 2',5'-Dimethoxyacetophenone |
| Synonyms: | Methyl 2,5-dimethoxyphenyl ketone;2,5-Dimethoxy acetonphenone;2',5'-Dimethoxyacetophenone,99%;2',5'-Dimethoxyaceto;1-(2,5-dimethoxyphenyl)-ethanon;Acetophenone, 2',5'-dimethoxy-;AKOS BBS-00004326;1-(2,5-dimethoxyphenyl)-ethanone |
| CAS: | 1201-38-3 |
| MF: | C10H12O3 |
| MW: | 180.2 |
| EINECS: | 214-858-0 |
| Product Categories: | Aromatic Acetophenones & Derivatives (substituted);C10;Carbonyl Compounds;Ketones;Acetophenone series;1201-38-3 |
| Mol File: | 1201-38-3.mol |
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2',5'-Dimethoxyacetophenone Chemical Properties
| Melting point | 18-20 °C(lit.) |
| Boiling point | 155-158 °C11 mm Hg(lit.) |
| density | 1.139 g/mL at 25 °C(lit.) |
| refractive index | n20/D 1.5441(lit.) |
| Fp | >230 °F |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform, Methanol (Slightly) |
| form | oily liquid |
| color | Clear yellow to green-yellow |
| BRN | 2047423 |
| InChI | 1S/C10H12O3/c1-7(11)9-6-8(12-2)4-5-10(9)13-3/h4-6H,1-3H3 |
| InChIKey | FAXUIYJKGGUCBO-UHFFFAOYSA-N |
| SMILES | COc1ccc(OC)c(c1)C(C)=O |
| LogP | 2.125 (est) |
| CAS DataBase Reference | 1201-38-3(CAS DataBase Reference) |
| NIST Chemistry Reference | Ethanone, 1-(2,5-dimethoxyphenyl)-(1201-38-3) |
| EPA Substance Registry System | Ethanone, 1-(2,5-dimethoxyphenyl)- (1201-38-3) |
Safety Information
| Hazard Codes | Xi |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| TSCA | TSCA listed |
| HazardClass | IRRITANT |
| HS Code | 29145090 |
| Storage Class | 11 - Combustible Solids |
2',5'-Dimethoxyacetophenone Usage And Synthesis
| Chemical Properties | clear yellow to green-yellow liquid |
| Uses | 2',5'-Dimethoxyacetophenone is a useful building block which has been used in the preparation of pyridine and thieno[2,3-b] pyridine derivatives as anticancer PIM-1 kinase inhibitors, and in the synthesis of anti-cancer and apoptosis-inducing agents. |
| Preparation | 2',5'-Dimethoxyacetophenone is obtained by reaction of dimethyl sulfate with quinacetophenone in the presence of 10% aqueous sodium hydroxide. |
| Synthesis | 2',5'-Dimethoxyacetophenone is prepared from Hydroquinone dimethylether and Acetic anhydride with Aluminum chloride catalyst. |
| References | [1] Tetrahedron Letters, 2011, vol. 52, # 38, p. 4954 - 4956
[2] Catalysis Communications, 2012, vol. 20, p. 68 - 70
[3] Tetrahedron Letters, 2013, vol. 54, # 23, p. 2924 - 2928 |
2',5'-Dimethoxyacetophenone Preparation Products And Raw materials
| Raw materials | 1-(2,5-DIMETHOXYPHENYL)ETHANOL-->Acetyl chloride-->Acetic anhydride-->Benzene, 2-ethenyl-1,4-diMethoxy--->1,4-Dimethoxybenzene-->Toluene-->Oxygen |
| Preparation Products | (2,5-Dimethoxyphenyl)acetic acid-->2-Propen-1-one, 3-(4-chlorophenyl)-1-(2,5-dimethoxyphenyl)--->1-(2,5-DIMETHOXY-PHENYL)-ETHYLAMINE-->(2E)-3-(3-chlorophenyl)-1-(2,5-dimethoxyphenyl)prop-2-en-1-one-->3-( 2,5-dimethowy-phenyl)-3-oxo-propionic acid ethyl ester-->Benzenemethanamine, 2,5-dimethoxy-α-methyl-, (αS)- |
