Introduction：Basic information about 2,9,10-Trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-3-ol CAS 3621-38-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Table of Contents
- 1. 2,9,10-Trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-3-ol Basic information
- 2. 2,9,10-Trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-3-ol Chemical Properties
- 3. Safety Information
- 4. 2,9,10-Trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-3-ol Usage And Synthesis
- 5. 2,9,10-Trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-3-ol Preparation Products And Raw materials
2,9,10-Trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-3-ol Basic information
| Product Name: | 2,9,10-Trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-3-ol |
| Synonyms: | Jatrorrhizin;2,9,10-Trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-3-ol;2,9,10-trimethoxy-;Dibenzo[a,g]quinolizinium, 5,6-dihydro-3-hydroxy-;Neprotin;Neprotine;Yatrorizine;5,6-Dihydro-3-hydroxy-2,9,10-trimethoxyberbinium |
| CAS: | 3621-38-3 |
| MF: | C20H20INO4 |
| MW: | 465.28 |
| EINECS: | 222-817-3 |
| Product Categories: | Alkaloids |
| Mol File: | 3621-38-3.mol |
|
2,9,10-Trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-3-ol Chemical Properties
| Melting point | 208～210℃ |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Methanol (Slightly, Heated) |
| form | Solid |
| color | Orange |
| Stability: | Hygroscopic |
| InChIKey | MXTLAHSTUOXGQF-UHFFFAOYSA-O |
Safety Information
| Hazard Codes | N |
| Risk Statements | 50 |
| Safety Statements | 61 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | 3 |
2,9,10-Trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-3-ol Usage And Synthesis
| Description | An alkaloid from Mahonia nepalensis DC. (Syn. Berberis nepalensis Spreng), this base is optically inactive and forms garnet-red crystals which decompose on heat_x0002_ing. The base contains 3.5 mole of H20 and still retains 1 mole even or prolonged drying at 100°C in vacuo. The salts are said to be orange or yellow. |
| Uses | Jatrorrhizine, is an alkaloid extract from the Berberidaceae family of plants displaying antioxidant activity. |
| Definition | ChEBI: Jatrorrhizine is an alkaloid. |
| in vivo | Jatrorrhizine (intraperitoneal?injection; 5, 10, 20 mg/kg) can significantly reduce the duration of immobility when compared with vehicle control group in tail suspension test (TST)[2]. | Animal Model: | Male ICR albino mice[2] | | Dosage: | 5, 10, 20 mg/kg | | Administration: | Intraperitoneal?injection; 5, 10, 20 mg/kg | | Result: | Reduced immobility period in tail suspension test. |
|
| target | LDL | P450 (e.g. CYP17) | NOS | COX | 5-HT Receptor | HMG-CoA Reductase |
| IC 50 | AChE |
| References | Chatterjee., Sci. & Cult., 7,619 (1942)
Chatterjee.,J. Amer. Pharm. Assoc., 33,205,210 (1944) |
2,9,10-Trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-3-ol Preparation Products And Raw materials
