Introduction：Basic information about 25 MG CALPAIN INHIBITOR IIRESEARCH GRADE CAS 136632-32-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
25 MG CALPAIN INHIBITOR IIRESEARCH GRADE Basic information
| Product Name: | 25 MG CALPAIN INHIBITOR IIRESEARCH GRADE |
| Synonyms: | Calpain Inhibitor II, ALLM;CALPAIN INHIBITOR II (N-AC-LEU-LEU METHIORINAL);N-acetyl-Leu-Leu-methional;ALLM (Calpain Inhibitor) 95% purity;ALLM (Calpain Inhibitor);25 MG CALPAIN INHIBITOR IIRESEARCH GRADE;Calpain Inhibitor II powder;ALLM (Ac-Leu-Leu-Met-CHO) |
| CAS: | 136632-32-1 |
| MF: | C19H35N3O4S1 |
| MW: | 401.56 |
| EINECS: | 603-969-3 |
| Product Categories: | Protease;Nitric Oxide and Cell;A to C;Aldehydes;and Substrates;Apoptosis Enzymes;Application Index;Bioactive Small Molecules;Biochemicals and Reagents;Building Blocks;C13-C60;Calpain;Calpain and Proteasome Inhibitors;ProteasomeInhibitors;Intracellular Protein Degradation;Lysosomal Proteases;Substrates;Calpain I;Calpain I Inhibitors;Calpain II;Calpain II Inhibitors;Carbonyl Compounds;Cathepsin B;Cathepsin/Granzyme Inhibitors &C-CH;Cell Biology;Cell Signaling and Neuroscience;Cell Signaling Enzymes;Chemical Synthesis;Endoplasmic Reticulum Stress;Enzyme Inhibitors;Enzyme Inhibitors by Enzyme;Enzymes;Inhibitors |
| Mol File: | Mol File |
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25 MG CALPAIN INHIBITOR IIRESEARCH GRADE Chemical Properties
| storage temp. | −20°C |
| solubility | Soluble in ethanol at 20mg/ml |
| form | powder |
| color | white |
| BRN | 7693643 |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
Safety Information
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| F | 3-10 |
25 MG CALPAIN INHIBITOR IIRESEARCH GRADE Usage And Synthesis
| Description | ALLM (136632-32-1) is a cell-permeable, peptide aldehyde inhibitor of calpain (calpain I, Ki?= 120 nM, calpain II, Ki?= 230 nM) and other neutral cysteine proteases. Potent inhibitor of cathepsin L (Ki=0.6 nM) and cathepsin B (Ki=100 nM).1?Weak inhibitor of the chymotrypsin-like activity of the proteasome.2?Cell permeable. |
| Uses | Calpain inhibitor II is a cell-permeable peptide that restricts the activity of calpain, cathepsin L and cathepsin B. Calpain inhibitor II also prevents the methylmercury-induced cell death of cultured rat cerebellar neurons. |
| Uses | ALLM (Calpain Inhibitor) is a cell-permeable, peptide aldehyde inhibitor of calpain I and calpain II. ALLM acts as a very potent inhibitor of cathepsin L and the strongest inhibitor of cathepsin B amongst the peptide aldehydes. This compound inhibits the processing of malaria aspartic hemoglobinases plasmepsins I and II?in vitro. ALLM also inhibits other neutral cysteine proteases, and activation-induced programmed cell death. It restores defective immune responses in HIV+ donors. ALLM blocks nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. ALLM also acts as a weak inhibitor of proteasome. |
| Definition | ChEBI: (2S)-2-acetamido-4-methyl-N-[4-methyl-1-[[4-(methylthio)-1-oxobutan-2-yl]amino]-1-oxopentan-2-yl]pentanamide is a peptide. |
| References | [1] T SASAKI. Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins.[J]. Journal of enzyme inhibition, 1990, 3 3: 195-201. DOI:10.3109/14756369009035837
[2] ALEXANDER VINITSKY. Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex[J]. Biochemistry Biochemistry, 1992, 31 39: 9421-9428. DOI:10.1021/bi00154a014 |
25 MG CALPAIN INHIBITOR IIRESEARCH GRADE Preparation Products And Raw materials
