Introduction：Basic information about 2-Acetyl-6-methoxynaphthalene CAS 3900-45-6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
2-Acetyl-6-methoxynaphthalene Basic information
| Product Name: | 2-Acetyl-6-methoxynaphthalene |
| Synonyms: | 1-(6-Methoxy-2-naphehalenyl)ethanone;6-ACETYL-2-METHOXYNAPHTHALENE;6-Methoxy-2-acetyInaphthalene;2-Acetyl-6-Methoxynaphthalene, 98% 10GR;1-(6-Methoxy-2-naphthalenyl)ethanone;1-(2-Methoxynaphthalen-6-yl)ethanone;2'-Acetonaphthone, 6'-Methoxy- (6CI,7CI,8CI);NSC 105564 |
| CAS: | 3900-45-6 |
| MF: | C13H12O2 |
| MW: | 200.23 |
| EINECS: | 223-453-8 |
| Product Categories: | Aromatics, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;Miscellaneous;C13 to C14;Carbonyl Compounds;Ketones;Aromatics;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol File: | 3900-45-6.mol |
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2-Acetyl-6-methoxynaphthalene Chemical Properties
| Melting point | 107-109 °C(lit.) |
| Boiling point | 155-160°C 0,4mm |
| density | 1.0907 (rough estimate) |
| vapor pressure | 0.009Pa at 25℃ |
| refractive index | 1.5906 (estimate) |
| Fp | 155-160°C/0.4mm |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Powder |
| color | Light yellow-beige |
| Water Solubility | 760mg/L at 27℃ |
| BRN | 1871098 |
| InChI | InChI=1S/C13H12O2/c1-9(14)10-3-4-12-8-13(15-2)6-5-11(12)7-10/h3-8H,1-2H3 |
| InChIKey | GGWCZBGAIGGTDA-UHFFFAOYSA-N |
| SMILES | C(=O)(C1=CC=C2C(=C1)C=CC(OC)=C2)C |
| LogP | 1.52 at 27℃ |
| CAS DataBase Reference | 3900-45-6(CAS DataBase Reference) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 37/38-36/37/38 |
| Safety Statements | 37/39-26-36/37 |
| WGK Germany | 3 |
| Hazard Note | Irritant |
| HS Code | 29145000 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Aquatic Chronic 2
Skin Irrit. 2 |
2-Acetyl-6-methoxynaphthalene Usage And Synthesis
| Chemical Properties | Light yellow-beige powder |
| Uses | Naproxen impurity L. Naproxen USP Related Compound L |
| General Description | 6′-Methoxy-2′-acetonaphthone (6-methoxy-2-naphthylacetic acid ) is metabolite of nabumetone, a phototoxic nonsteroidal antiinflammatory drug.1 |
| Flammability and Explosibility | Non flammable |
2-Acetyl-6-methoxynaphthalene Preparation Products And Raw materials
| Raw materials | Ethanol-->Methanol-->Sulfuric acid-->Aluminum chloride-->Acetyl chloride-->2-Naphthol-->Nitrobenzene-->2-Methoxynaphthalene-->1-(6-methoxy-1-naphthyl)ethan-1-one-->2-Naphthaleneacetic acid, 6-methoxy-α-methylene-, methyl ester-->2-ETHYNYL-6-METHOXYNAPHTHALENE 97-->6-METHOXY-2-(1-METHYLVINYL)NAPHTHALENE-->2-Methoxy-1-acetonaphthone-->2-ACETYL-5-BROMO-6-METHOXYNAPHTHALENE-->(+/-)-2-(6-METHOXY-2-NAPHTHYL)PROPIONIC ACID |
| Preparation Products | ETHYL 3-(6-METHOXY-2-NAPHTHYL)-3-METHYL GLYCIDATE-->METHYL 3-(6-METHOXY-2-NAPHTHYL)-3-METHYL GLYCIDATE-->Naproxen-->6-methoxy-alpha-methylnaphthalen-1-acetaldehyde-->6-ETHYL-2-METHOXYLNAPHTHALINE |
