2-Acetylfuran CAS 1192-62-7
Introduction：Basic information about 2-Acetylfuran CAS 1192-62-7, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
2-Acetylfuran Basic informationAroma
| Product Name: | 2-Acetylfuran |
| Synonyms: | -(2-Furanyl)-ethanone;1-(2-furanyl)-ethanon;1-(2-Furanyl)-ethanone (2-acetylfuran);1-(2-furanyl)ethanone (acetylfuran);1-(2-Furyl)ethanone;1-furan-2-yl-ethanone;2-acetyl-fura;2-acetylfurane |
| CAS: | 1192-62-7 |
| MF: | C6H6O2 |
| MW: | 110.11 |
| EINECS: | 214-757-1 |
| Product Categories: | pharm intermediate;orgainic intermediates;ACETYLGROUP;Aromatic Ketones (substituted);Furan&Benzofuran;Furans;furnan Flavor;1192-62-7;VX:15689727968 |
| Mol File: | 1192-62-7.mol |
2-Acetylfuran Chemical Properties
| Melting point | 26-28 °C(lit.) |
| Boiling point | 67 °C10 mm Hg(lit.) |
| density | 1.098 g/mL at 25 °C(lit.) |
| FEMA | 3163 | 2-FURYL METHYL KETONE |
| refractive index | n |
| Fp | 160 °F |
| storage temp. | 2-8°C |
| solubility | >51.2 mg/mL in DMSO; >52 mg/mL in EtOH |
| form | Liquid or Low Melting Solid |
| color | light yellow to orange, darkens over time |
| Specific Gravity | 1.098 |
| Odor | at 1.00 % in dipropylene glycol. sweet balsam almond cocoa caramel coffee |
| Odor Type | balsamic |
| biological source | synthetic |
| explosive limit | 2.1-15.2%(V) |
| Water Solubility | Insoluble in water. |
| JECFA Number | 1503 |
| BRN | 107909 |
| Major Application | cleaning products cosmetics flavors and fragrances food and beverages personal care |
| Cosmetics Ingredients Functions | PERFUMING |
| InChI | 1S/C6H6O2/c1-5(7)6-3-2-4-8-6/h2-4H,1H3 |
| InChIKey | IEMMBWWQXVXBEU-UHFFFAOYSA-N |
| SMILES | CC(=O)c1ccco1 |
| LogP | 0.52 |
| CAS DataBase Reference | 1192-62-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Ethanone, 1-(2-furanyl)-(1192-62-7) |
| EPA Substance Registry System | 2-Acetylfuran (1192-62-7) |
Safety Information
| Hazard Codes | T |
| Risk Statements | 20/21-25-41-36/37-23/25 |
| Safety Statements | 26-36/37/39-45-39-38-28A |
| RIDADR | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | OB3870000 |
| Hazard Note | Toxic |
| TSCA | TSCA listed |
| HazardClass | 6.1 |
| PackingGroup | II |
| HS Code | 29321900 |
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
| Hazard Classifications | Acute Tox. 2 Inhalation Acute Tox. 2 Oral Acute Tox. 3 Dermal Eye Irrit. 2 |
| Toxicity | rat,LC50,inhalation,1130mg/m3/4H (1130mg/m3),BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLDLUNGS, THORAX, OR RESPIRATION: DYSPNEA,National Technical Information Service. Vol. OTS0559116, |
| Aroma | Powerful bakamic-sweet odor with a tobacco-like, almost narcotic pungency. Floralundertones are of balsamic-cinnamic character. |
| Chemical Properties | 2-Acetylfuran is a gold-colored solid with an odor of sweet balsam almond cocoa, caramel coffee. It is incompatible with strong oxidizing agents, strong reducing agents, and strong bases. It is combustible. On decomposition, 2-acetylfuran releases carbon monoxide and carbon dioxide. It is insoluble in water, but soluble in alcohol, dipropylene glycol, and ethyl ether. natural products exist in the volatile aroma components of coffee, tomatoes, beer, green tea, raisins and potato chips, etc. |
| Occurrence | 2-Acetylfuran is the most abundant flavour compound in Tamarind, where its aroma, in conjunction with alpha-terpineol, citral and some trace pyrazines, contributes to the flavour. Reported found as a constituent in coffee aroma; also isolated from beech and oak wood tar oils; an aroma component of yellow passion fruit (Passiflora edulis f. flavicarpa); also a volatile flavor component of potato chips. Also reported in tomato paste, roasted beef, grilled pork, beer, rum, red wine and green tea. |
| Uses | 2-Acetylfuran is a useful intermediate in the synthesis of fine chemicals and pharmaceuticals, and is used in the production of the generic cephalophosphorin antibiotic cefuroxime |
| Uses | 2-Acetylfuran is a widely used reagent in manufacturing pharmaceuticals and aroma compounds. |
| Definition | ChEBI: 2-acetylfuran is a furan carrying an acetyl substituent at the 2-position. Used in the production of the antibiotic cefuroxime (CHEBI:3515). It is a member of furans, a methyl ketone and an aromatic ketone. |
| Preparation | 2-Acetylfuran is synthesized from furan and acetyl chloride by a Friedel–Kraft condensation. |
| Aroma threshold values | Detection: 10 ppm |
| General Description | 2-Furyl methyl ketone is a volatile heterocyclic flavor compound that may be formed in food due to Maillard reaction. It has been reported in roasted sesame seeds, fried beef and sweet corn products. |
| Health Hazard | Exposures to 2-acetylfuran by ingestion, inhalation, and skin absorption cause harmfuleffects. It causes irritation to the skin, the eyes, coughing, respiratory tract irritation, andrespiratory distress. Accidental ingestion causes irritation of the digestive tract. There areno data about chronic exposure and adverse effects. |
| Biological Activity | Taste at 10 ppm |
| Solubility in organics | Soluble in Ethyl alcohol, essential oils, perfume and flavor chemicals and in Propyleneglycol. |
| storage | 2-Acetylfuran should be kept away from sources of ignition, heat, sparks, flame, and light.It should be kept stored in a tightly sealed container in a dry area/refrigerated (below4°C/39°F). |
| Precautions | During handling and use of 2-acetylfuran, occupational workers should use appropriateand proper personal protective equipment and wear a self-contained breathing apparatus.Workers should avoid generating dusty conditions, minimize generation and accumulationof dust, remove all sources of ignition, and use a spark-proof tool. Workers should use2-acetylfuran only in a chemical fume hood. |
2-Acetylfuran Preparation Products And Raw materials
| Raw materials | Acetyl chloride-->Furan |
| Preparation Products | 3-Hydroxy-2-methylpyridine-->5-(2-FURYL)-4H-PYRAZOLE-3-CARBOXYLIC ACID-->3-(Furan-2-yl)-1H-pyrazole-5-carboxamide ,97%-->3-(Furan-2-yl)-1H-pyrazole-5-carbohydrazide ,97%-->1-(5-NITRO-2-FURYL)ETHANONE-->N,N-Dimethylformamide dimethyl acetal-->4,4,4-TRIFLUORO-1-(2-FURYL)-1,3-BUTANEDIONE-->ETHYL 5-(2-FURYL)-1H-PYRAZOLE-3-CARBOXYLATE-->(2-FURYL)GLYOXYLIC ACID-->Ethanone, 1-[5-(4-bromophenyl)-2-furanyl]--->2-[1-(2-FURYL)ETHYLIDENE]MALONONITRILE-->1-(5-BENZYL-2-FURYL)ETHANONE-->3-(4-(Dimethylamino)phenyl)-1-(furan-2-yl)prop-2-en-1-one-->DL-1-(2,5-DIMETHOXY-2,5-DIHYDROFURAN-2-YL)ETHANOL |
