Introduction：Basic information about 2-Adamantanamine hydrochloride CAS 10523-68-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
2-Adamantanamine hydrochloride Basic information
| Product Name: | 2-Adamantanamine hydrochloride |
| Synonyms: | tricyclo(3.3.1.1(sup3,7))decan-2-amine,hydrochloride;2-ADAMANTYLAMINE HYDROCHLORIDE;2-ADAMANTANAMINE HYDROCHLORIDE;2-AMINOADAMANTANE HYDROCHLORIDE;2-Adamantamine hydrochloride 98+%;tricyclo(3.3.1.13.7)dec-2-ylamine hydrochloride;adamantan-2-amine hydrochloride;2-ADAMANTANAMINE HCL |
| CAS: | 10523-68-9 |
| MF: | C10H18ClN |
| MW: | 187.71 |
| EINECS: | 234-074-2 |
| Product Categories: | Adamantanes;Adamantane derivatives |
| Mol File: | 10523-68-9.mol |
|
2-Adamantanamine hydrochloride Chemical Properties
| Melting point | >300 °C(lit.) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| form | Crystalline Powder |
| color | White |
| Water Solubility | soluble |
| BRN | 4297901 |
| InChI | InChI=1/C10H17N.ClH/c11-10-8-2-6-1-7(4-8)5-9(10)3-6;/h6-10H,1-5,11H2;1H/t6-,7+,8-,9+,10?; |
| InChIKey | WLDWDRZITJEWRJ-ZDAMNCSYNA-N |
| SMILES | C1(N)[C@@]2([H])C[C@]3([H])C[C@]([H])(C2)C[C@@]1([H])C3.Cl |&1:2,5,8,12,r| |
| CAS DataBase Reference | 10523-68-9(CAS DataBase Reference) |
Safety Information
| Hazard Codes | Xi,Xn |
| Risk Statements | 36/37/38-22 |
| Safety Statements | 26-36-36/37/39-22 |
| WGK Germany | 3 |
| RTECS | AU4375100 |
| F | 10 |
| HazardClass | IRRITANT |
| HS Code | 29213000 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
2-Adamantanamine hydrochloride Usage And Synthesis
| Chemical Properties | white crystalline powder |
| Uses | 2-Adamantylamine hydrochloride was used to prepare 2-adamantylamide of 2?-(carboxymethoxime)-olivomycin I. The HPLC assay of 2-adamantylamine hydrochloride after pre-column derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole has been studied. It is also used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff. |
| Uses | 2-Adamantanamine Hydrochloride can be used to prepare CD73 inhibitors to treat CD73-associated diseases, including cancer and immune-related disorders. |
| General Description | The HPLC assay of 2-adamantylamine hydrochloride after pre-column derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole has been studied. |
| Purification Methods | The free amine in Et2O, liberated by the action of alkali in H2O, is dried over KOH, filtered, evaporated and sublimed at 110o/12torr, m 230-236o. The base is dissolved in EtOH, sufficient ethanolic HCl is added dropwise and crystallised by the addition of Et2O. Dry it in vacuo. [Stetter et al. Justus Liebigs Ann Chem 658 151 1962]. |
2-Adamantanamine hydrochloride Preparation Products And Raw materials
| Preparation Products | 2-Adamantanol-->1-Adamantanamine hydrochloride |
